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Hops Tincture ( Humulus lupulus ) - 50 ml

R 9200
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Description

Hops Tincture (Humulus lupulus) - 50 ml


     

     

    TRADITIONALLY USED FOR

     May help with
     

    • sedative - analgesic
    • antibacterial
    • strong estrogenic
    • effective against hot flushes
    • menopausal discomfort
    • nervous insomnia

    INFORMATION

    Source : http://www.wikiphyto.org/wiki/Houblon

     

    Reference on http://www.wikiphyto.org

     

    Translation in English by Google Translate  (go to the page of the source linked | on Chrome cellphones go on the 3 dots on the top right and select translate in your preferred language | on laptop right click your mouse and select option translate when hoovering on the page

     

    plant name

     

    Hop, hop (English)

     

    International Latin denomination

     

    Humulus lupulus L.

     

    botanical family

     

    Cannabaceae

     

    Description and habitat

     

    • Perennial dioecious lianoid herbaceous plant, with opposite lobed leaves, ovoid yellow-greenish female flowers grouped in clusters, formed of membranous scales (bracts and bracteoles) which bear lupulin (oleoresin) glands in red-orange grains

     

    History and tradition

     

    • Cultivated for the production of beer from the 8th century in Germany
    • Produced by hop fields in many countries with a temperate climate (Alsace, temperate Europe)

     

    Parts used

     

    • Dried female inflorescence (called “cone” or strobile)

     

    Dosage forms available

     

     

    Usual dosages

     

    Composition

     

    Main components of the plant

     

     

    Main components of buds or young shoots

     

    Main components of essential oil

     

     

    Properties

     

    Plant properties

     

    • Sedative, antibacterial activity
    • Analgesic, effect mediated by opioid receptors, but not by serotonergic or alpha(2)-adrenergic receptors [1]
    • Powerfully estrogenic [2] by various polyphenols  : isoflavones , chalcones (including xanthohumol ), prenylated flavones including especially 8-prenyl-naringenin (= hopein ): at a dose of 30mg/Kg body weight in rats for 14 days, l enlargement of the uterus is the same as that obtained with 0.01mg/Kg of estradiol (3000 times lower activity in molecular weight ratio) [3] , [4]
    • The activity is identical at the level of the alpha and beta estrogen receptors [5]
    • Isoxanthohumol , weakly phytoestrogenic can be bioactivated by 8-prenyl-naringenin [6] , [7] , with intervention of the saprophytic flora (microbiota) [8]
    • 8- prenyl -naringenin inhibits angiogenesis in vitro and in vivo [9]
    • Effective on hot flushes with 8-prenyl-naringenin at a dose of 400 µg/kg [10] , and on menopausal discomfort [11] , [12]

     

    Bud properties

     

    Properties of essential oil

     

    Directions

     

    Indications of the whole plant (phytotherapy)

     

    • Disorders of the menopause, hot flashes, hops would decrease the body temperature [13]
    • Instability, hyperexcitability, insomnia of nervous origin and states of stress
    • Sleep onset insomnia during menopause
    • Symptomatic treatment of neurotonic states in adults and children, especially in cases of minor sleep disorders
    • appetite stimulation
    • female hirsutism (?)

     

    Indications of the bud (gemmotherapy)

     

    Specific indications of essential oil (aromatherapy)

     

    Known or suspected mode of action

     

    • Methylbutenol formed from humulone and lupulone can be considered as one of the active ingredients, its content increases during storage
    • Hopein (= 8- prenyl -naringenin ) is potently estrogenic, and at a dose of 30 mg/Kg of body weight in rats for 14 days, the increase in the uterus is the same as that obtained with 0.01 mg/ Kg of estradiol (source AFSSAPS)

     

    Usual formulations

     

     

    Regulations

     

     

    Possible side effects and precautions for use

     

    • Contraindicated in mastosis and history of breast cancer, hormone-dependent cancers

     

    Bibliographic references

     

    1. Aller↑ Park SH, Sim YB, Kang YJ, Kim SS, Kim CH, Kim SJ, Seo JY, Lim SM, Suh HW. Hop extract produces antinociception by acting on opioid system in mice. Korean J Physiol Pharmacol. 2012 Jun;16(3):187-92. PMID 22802700
    2. Aller↑ Chadwick LR, Pauli GF, Farnsworth NR. The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on estrogenic properties. Phytomedicine. 2006 Jan;13(1-2):119-31. PMID 16360942
    3. Aller↑ AFSSA, AFSSAPS. Safety and benefits of dietary phytoestrogens - Recommendations. March 2005 full text
    4. Aller↑ Milligan SR, Kalita JC, Pocock V, Van De Kauter V, Stevens JF, Deinzer ML, Rong H, De Keukeleire D. The endocrine activities of 8-prenylnaringenin and related hop (Humulus lupulus L.) flavonoids. J Clin Endocrinol Metab. 2000 Dec;85(12):4912-5. PMID 1113416
    5. Aller↑ S Milligan, J Kalita, V Pocock, A Heyerick, L De Cooman, H Rong, and D De Keukeleire. Estrogenic activity of the hop phyto-oestrogen, 8-prenylnaringenin. Breeding (2002) 123 235-242. PMID 11866690 full text
    6. Aller↑ Bolca S, Possemiers S, Maervoet V, Huybrechts I, Heyerick A, Vervarcke S, Depypere H, De Keukeleire D, Bracke M, De Henauw S, Verstraete W, Van De Wiele T. Microbial and dietary factors associated with the 8- prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women. British journal of nutrition. 2007, vol. 98, no.5, p. 950-959 [1]
    7. Aller↑ Cassia R. Overk, Ping Yao, Lucas R. Chadwick, Dejan Nikolic, Yongkai Sun, Muriel A. Cuendet, Yunfan Deng, AS Hedayat, Guido F. Pauli, Norman R. Farnsworth, Richard B. van Breemen, Judy L. Bolton. Comparison of the In Vitro Estrogenic Activities of Compounds from Hops (Humulus lupulus) and Red Clover (Trifolium pratense). J Agric Food Chem. 2005 August 10; 53(16): 6246–6253 [2]
    8. Aller↑ Sam Possemiers, Arne Heyerick, Veerle Robbens, Denis De Keukeleire, Willy Verstraete. Activation of Proestrogens from Hops (Humulus lupulus L.) by Intestinal Microbiota; Conversion of Isoxanthohumol into 8-Prenylnaringenin. Journal of Agricultural and Food Chemistry 2005 53 (16), 6281-6288 [3]
    9. Aller↑ Pepper Michael S, Hazel Susan J, Hümpel Michael, Schleuning Wolf-Dieter. 8-prenylnaringenin, a novel phytoestrogen, inhibits angiogenesis in vitro and in vivo. J.Cell. Physiol. 199: 98-107, 2004 [4]
    10. Aller↑ James Bowe, Xiao Feng Li, James Kinsey-Jones, Arne Heyerick1, Susan Brain2, Stuart Milligan and Kevin O'Byrne. The hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushes. Journal of Endocrinology (2006) 191, 399-405 [5]
    11. Aller↑ R. Erkkola, S. Vervarcke, S. Vansteelandt, P. Rompotti, D. De Keukeleire, A. Heyerick. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine 17 (2010) 389–396 PMID 20167461
    12. Aller↑ Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas. 2006 May 20;54(2):164-75. PMID 16321485
    13. Aller↑ Goetz P. The role of hops and its constituents in the treatment of menopause. Phytotherapy, April 2007, Volume 5, Issue 2, pp 83–85

    CAUTION

    Store in a cool, dry place, away from light. Keep tightly closed, away from the reach of Children and pets.

    Do not exceed the daily dose.

     

    This product is not intended to prevent or cure any form of illness or disease.
     

    If you are pregnant or nursing ; If you have a medical condition or are in the course of medical treatment ; If you are programmed for theater/operation in the near future, please consult your healthcare practitioner before using this product.

     

    This product cannot replace a varied and balanced diet and a healthy lifestyle.

     

    This product has not been evaluated by the SAHPRA for its quality, safety or intended use.