Motherwort herb, derived from the Leonurus cardiaca plant, is a traditional herbal remedy with various properties and benefits:

1. Uterine Tonic: Motherwort is known for its ability to strengthen and tone the uterus, making it beneficial for women's reproductive health, particularly during menstruation and childbirth.
2. Cardiovascular Support: Motherwort may help regulate heart function and support cardiovascular health due to its calming effects on the heart and blood vessels.
3. Nervine: Motherwort has a calming effect on the nervous system, making it useful for alleviating stress, anxiety, and nervous tension.
4. Antispasmodic: Motherwort possesses antispasmodic properties that can help reduce muscle spasms, cramps, and discomfort associated with menstruation.
5. Hormonal Balance: Motherwort may help regulate hormonal imbalances, particularly in women, and alleviate symptoms of premenstrual syndrome (PMS) and menopause.
6. Diuretic: Motherwort acts as a mild diuretic, which can help the body eliminate excess fluids and reduce bloating.
7. Anti-inflammatory: Motherwort has anti-inflammatory properties that may help reduce inflammation and alleviate symptoms associated with inflammatory conditions.

Note: While motherwort offers numerous benefits, it is essential to use it responsibly and consult a healthcare professional before incorporating it into your routine, especially if you are pregnant, nursing, or have a pre-existing health condition.

Source : http://www.wikiphyto.org/wiki/motherswort

Reference on http://www.wikiphyto.org

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plant name

Motherwort, cardiac

International Latin denomination

Leonurus cardiaca L.

botanical family

Lamiaceae

Description and habitat

• Perennial present in almost all of Europe and Asia, 60 to 150 cm, dark green leaves with whitish underside, deeply cut in acute lobes, flowers arranged in long spikes of glomeruli
• Calyx with spiny teeth, long corolla purple or pink, +/- punctate, pubescent
• The 4 parts of the fruit are trigonal and hairy

History and tradition

• Its action on the heart and the circulation justifies its other name Cardiac

Parts used

• Aerial parts

Dosage forms available

• mother tincture, tincture

Usual dosages

• For the Pharmacopoeia, minimum 0.2% flavonoids (expressed as hyperoside )

Composition

Main components of the plant

• Iridoids  : ajugol , galiridoside , reptoside , leonuride = ajugoside , leonurine , 7R-chloro-6-deoxy-harpagide
• Monoterpenes
• Diterpenes  : labdanolides ( leocardine , isolateosibirine )
• Triterpenes  : ursolic acid , oleanolic acid
• Phenylpropanoid derivatives  : verbascoside , lavandulifolioside ( phenylethanoid )
• Bitter glycosides of the bufanolide group
• Flavonoids  : quercetol glycosides , kæmpferol , apigenin , acid-phenols , hyperoside
• Saponosides
• Tannins , phenolic acids , sterols
• Stachydrin , leonurine (nitrogen compounds)

Main components of buds or young shoots

Main components of essential oil

Properties

Plant properties

• Mildly cardiac tonic ( bufanolide group glucosides ) and hypotensive ( lavandulifolioside ), negative chronotropic, prolongation of the PQ interval, QT intervals and QRS complex [1]
• Anti-arrhythmic [2] ( stachydrin , triterpene acids  : oleanolic acid and ursolic acid )
• Sedative, tranquilizer by interaction with GABA -A receptors ( isolatosibirin (labdane-like compound), 7R-chloro-6-deoxy-harpagid ( iridoid ), lavandulifolioside (phenylethanoid), stachydrin , leonurine (nitrogen compounds) [3]
• Antihypertensive [4]
• Active in tachycardia of hyperthyroidism
• Inhibits platelet aggregation, vascular relaxant, cardiac protector (inhibits apoptosis induced by myocardial hypoxia) [5]
• Uterotonic [6] , oxytocic effect [7]
• Nephroprotective against renal fibrosis [8]
• Antibacterial
• Antioxidant [9] , immunomodulating [10] , anti-inflammatory, analgesic [11]

Bud properties

Properties of essential oil

Directions

Indications of the whole plant (phytotherapy)

• High blood pressure, especially if accompanied by anxiety and sleep disturbances [4]
• Functional neuro-vegetative disorders, menopausal disorders
• Nervous heart disorders
• bronchial asthma
• Disorders accompanying amenorrhea
• Tachycardias of hyperthyroidism

Indications of the bud (gemmotherapy)

Specific indications of essential oil (aromatherapy)

Known or suspected mode of action

Usual formulations

Regulations

• French Pharmacopoeia list A (flowering top)

Possible side effects and precautions for use

• Good tolerance [12]
• Contraindicated in pregnant women

Bibliographic references

1. Aller↑ Miłkowska-Leyck K, Filipek B, Strzelecka H. Pharmacological effects of lavandulifolioside from Leonurus cardiaca. J Ethnopharmacol. 2002 Apr;80(1):85-90. PMID 11891090
2. Aller↑ Ritter M, Melichar K, Strahler S, Kuchta K, Schulte J, Sartiani L, Cerbai E, Mugelli A, Mohr FW, Rauwald HW, Dhein S. Cardiac and electrophysiological effects of primary and refined extracts from Leonurus cardiaca L. (Ph .Eur.). PlantaMed. 2010 Apr;76(6):572-82. doi: 10.1055/s-0029-1240602. PMID 19918711
3. Aller↑ Rauwald, HW, Savtschenko, A., Merten, A., Rusch, C., Appel, K., & Kuchta, K. (2015). GABAA receptor binding assays of standardized Leonurus cardiaca and Leonurus japonicus extracts as well as their isolated constituents. Planta Medica, 81(12/13), 1103-1110.
4. ↑ Aller à :4.0 and 4.1 Shikov AN, Pozharitskaya ON, Makarov VG, Demchenko DV, Shikh EV. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res. 2011 Apr;25(4):540-3. doi: 10.1002/ptr.3292. PMID 20839214
5. Aller↑ Zhu Q, Zhang J, Yang P, et al. Characterization of Metabolites of Leonurine (SCM-198) in Rats after Oral Administration by Liquid Chromatography/Tandem Mass Spectrometry and NMR Spectrometry. The Scientific World Journal. 2014;2014:947946. doi:10.1155/2014/947946. Full Text
6. Aller↑ Yang M, Yang S, Jin Z, Zhu S. Study on the biological assay of Herba Leonuri--analysis the dosage response curve of Herba Leonuri and oxytocin and establishment of adequate potency pattern. Zhong Yao Cai. 2002 Jun;25(6):409-11. PMID 12583332
7. Aller↑ Lin JH, Lin QD, Liu XH, Yan JY, He J, Li L, Gu H, Sun LZ, Zhang JP, Yu S, Ma YY, Niu JM, Xia Y, Zhao SC, Li W, Wang HL, Wang BS. Multi-center study of motherwort injection to prevent postpartum hemorrhage after caesarian section. Zhonghua Fu Chan Ke Za Zhi. 2009 Mar;44(3):175-8. PMID 19570440
8. Aller↑ Cheng H, Bo Y, Shen W, Tan J, Jia Z, Xu C, Li F. Leonurine ameliorates kidney fibrosis via suppressing TGF-β and NF-κB signaling pathway in UUO mice. Int Immunopharmacol. 2015 Apr;25(2):406-15. doi: 10.1016/j.intimp.2015.02.023. PMID 25727888
9. Aller↑ Jafari, S., Moradi, A., Salaritabar, A., Hadjiakhoondi, A., & Khanavi, M. (2010). Determination of total phenolic and flavonoid contents of Leonurus cardiaca L. in compare with antioxidant activity. Research Journal of Biological Sciences, 5(7), 484-487.
10. Aller↑ Sadowska, B., Micota, B., Różalski, M., Redzynia, M., & Różalski, M. (2017). The immunomodulatory potential of Leonurus cardiaca extract in relation to endothelial cells and platelets. Innate Immunity, 23(3), 285-295.
11. Aller↑ Wojtyniak K, Szymański M, Matławska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res. 2013 Aug;27(8):1115-20. doi: 10.1002/ptr.4850. PMID 23042598
12. Aller↑ Han SR, Han HY, Lee BS, Min BS, Chung MK, Young Jeong J, Roh HS, Seok JH, Kim SK. Toxicity assessment of Leonuri Herba aqueous extract orally administered to rats for 13 consecutive weeks. J Ethnopharmacol. 2013 Aug 26;149(1):371-6. doi: 10.1016/j.jep.2013.06.053. PMID 23834914

• Liu XH, Pan LL, Zhu YZ. Active chemical compounds of traditional Chinese medicine Herba Leonuri: implications for cardiovascular diseases. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):274-82. doi: 10.1111/j.1440-1681.2011.05630.x. PMID 22004449
• John C Knight, George R Pettit, Peter Brown. Steroids and related natural products. LVII. Bufadienolides. 10. 3.beta.-Acetoxy-14.beta.,21-epoxy-5.beta.-bufanolide and related lactones. J.Org. Chem., 1970, 35 (5), pp 1415–1419
• Takahiro Tanase, Akito Nagatsu, Nobutoshi Murakami, Shin-ichi Nagai, Taisei Ueda, and all. Studies on cardiac ingredients of plants. XI. Synthesis of new bufotoxin homologs utilizing scillarenin (the genuine aglycon of proscillaridin), and their biological activities. Chemical Pharmaceutical Bulletin (1994), Volume: 42, Issue: 11, Publisher: Pharmaceutical Society of Japan, Pages: 2256-2262

Store in a cool, dry place, away from light. Keep tightly closed, away from the reach of Children and pets.

Do not exceed the daily dose.

This product is not intended to prevent or cure any form of illness or disease.
 

If you are pregnant or nursing ; If you have a medical condition or are in the course of medical treatment ; If you are programmed for theater/operation in the near future, please consult your healthcare practitioner before using this product.

This product cannot replace a varied and balanced diet and a healthy lifestyle.

This product has not been evaluated by the SAHPRA for its quality, safety or intended use.

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