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Passion Flower Tincture ( Passiflora incarnata ) - 50 ml

R 9900
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Description

Passion Flower Tincture (Passiflora incarnata flores - 50 ml

 

    TRADITIONALLY USED FOR

    May help with

     

    • sedative
    • anxiolytic
    • antispasmodic
    • anti depressant
    • neuropathic pain
    • anti addictive

    INFORMATION

    Source : http://www.wikiphyto.org/wiki/Passion Flower

     

    Reference on http://www.wikiphyto.org

     

    Translation in English by Google Translate  (go to the page of the source linked | on Chrome cellphones go on the 3 dots on the top right and select translate in your preferred language | on laptop right click your mouse and select option translate when hoovering on the page

     

    plant name

     

    Passionflower, passion flower

     

    International Latin denomination

     

    Passiflora incarnata L.

     

    botanical family

     

    Passifloraceae

     

    Description and habitat

     

    • Climbing plant with a woody stem native to the southern United States and Mexico
    • Cultivated in the United States, in the South of France, in Brittany and in Anjou
    • Alternate leaves deeply divided into three acute lobes of which the median is the most developed
    • The drug can be falsified by the leafy stems of Passiflora edulis (which gives passion fruit), almost inactive [1] or ornamental Passiflora coerulea which has five-lobed leaves

     

    History and tradition

     

    • Passionflower was known to the Aztecs
    • It was called " Passion flower " by the missionaries because each of the organs of the plant recalled the instruments of the Passion of Christ:
      • Three-pointed flowers: the spear
      • The tendrils: the whip
      • The three styles of the plant: nails
      • The stigmata: the sponge
    • While the colors (white and bluish purple) recall purity and paradise

     

    Parts used

     

    • Dried aerial parts which may contain flowers and/or fruits

     

    Dosage forms available

     

     

    Usual dosages

     

     

    Composition

     

    Main components of the plant

     

     

    Main components of buds or young shoots

     

    Main components of essential oil

     

    Properties

     

    Plant properties

     

     

    Bud properties

     

    Properties of essential oil

     

    Indications

     

    Indications of the whole plant (phytotherapy)

     

    • Anxiety and agitation [19]
    • Plant of the anxious restless (cerebral and sensory hyperexcitability, central and peripheral sedative)
    • Plant of nervous excitation and neuro-sensory hypersensitivity  " [20] (to noises, smells, various stresses), it soothes, relaxes, is active in withdrawal syndromes, no doubt thanks to its small quantity of ' indole alkaloids
    • Insomnia and sleep disturbances due to evening excitement, hyperemotivity
    • Cardiac erethism disorders in adults, neurotonic states in adults and children
    • Unstable hyperactive child, adult hyperactivity
    • Psychogenic abdominal pain, colitis
    • Neuropathic pain [21]
    • Delayed pituitary-adrenal response
    • Acts on the spasmodic and cortical (overactive brain) component of anxiety
    • Interesting in withdrawal from benzodiazepines, anti-addictive [22] , [23] , opiates [24] , cannabis [25]
    • It can be compared to Ignatia in homeopathy

     

    Indications of the bud (gemmotherapy)

     

    Specific indications of essential oil (aromatherapy)

     

    Known or suspected mode of action

     

     

    Usual formulations

     

    Regulations

     

     

    Possible side effects and precautions for use

     

    • Rare adverse effects (tachycardia, nausea, vomiting, drowsiness) [27] , [28]
    • Possible pharmacological interactions with benzodiazepines (lorazepam) [29]
    • Passionflower extracts containing the flavonoids orientin , apigenin , vitexin , could interact with organic anion transport polypeptides OATP2B1 and OATP1A2 and thus affect the absorption of certain hormones (estrone-3, pregnenolone, dehydroepiandrosterone sulfates) [30]
    • Contraindication in pregnant women ( alkaloids )

     

    Bibliographic references

     

    1. Go↑ Dhawan K, Kumar S, Sharma A. Comparative biological activity study on Passiflora incarnata and P. edulis. Fitoterapia. 2001 Aug;72(6):698-702. PMID 11543974
    2. Go↑ Baudou, M. (2019). Study of the alkaloids of the ß-carboline group reported in Passiflora officinale (Passiflora incarnata L.) (Doctoral dissertation, University of Toulouse III-Paul Sabatier).
    3. Go↑ Aoyagi N, Kimura R, Murata T. Studies on passiflora incarnata dry extract. I. Isolation of maltol and pharmacological action of maltol and ethyl maltol. Chem Pharm Bull (Tokyo). 1974 May;22(5):1008-13. PMID 4421168
    4. Go↑ Santos, APM, Galindo, AS, & de Souza Queiroz, E. (2020). Neuropsychopharmacological properties, chemically active compounds and medicinal use of passionflower incarnata. Brazilian Journal of Development, 6(12), 94823-94836.
    5. Go↑ Dhawan K, Kumar S, Sharma A. Anxiolytic activity of aerial and underground parts of Passiflora incarnata. Fitoterapia. 2001 Dec;72(8):922-6. PMID 11731118
    6. Go↑ Dhawan K, Dhawan S, Sharma A. Passiflora: a review update. J Ethnopharmacol. 2004 Sep;94(1):1-23. PMID 15261959
    7. Go↑ Soulimani R, Younos C, Jarmouni S, Bousta D, Misslin R, Mortier F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J Ethnopharmacol. 1997 Jun;57(1):11-20. PMID 9234160
    8. Go↑ Grundmann O, Wähling C, Staiger C, Butterweck V. Anxiolytic effects of a passion flower (Passiflora incarnata L.) extract in the elevated plus maze in mice. Pharmazie. 2009 Jan;64(1):63-4. PMID 19216234
    9. Go↑ Miyasaka LS, Atallah AN, Soares BGO. Passiflora for anxiety disorder. Cochrane Database of Systematic Reviews 2007, Issue 1. Art. No.: CD004518. DOI: 10.1002/14651858.CD004518.pub2. texte intégral Revue Cochrane
    10. Go↑ Grundmann O, Wang J, McGregor GP, Butterweck V. Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system. Planta Med. 2008 Dec;74(15):1769-73. PMID 19006051
    11. Go↑ Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G. Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res. 2011 Jun;25(6):838-43. doi: 10.1002/ptr.3352. PMID 21089181
    12. Go↑ Elsas SM, Rossi DJ, Raber J, White G, Seeley CA, Gregory WL, Mohr C, Pfankuch T, Soumyanath A. Passiflora incarnata L. (Passionflower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. Phytomedicine. 2010 Oct;17(12):940-9. PMID 20382514 texte intégral : [1]
    13. Go↑ de Oliveira, D. D., da Silva, C. P., Iglesias, B. B., & Beleboni, R. O. (2020). Vitexin Possesses Anticonvulsant and Anxiolytic-Like Effects in Murine Animal Models. Frontiers in pharmacology, 11, 1181. https://doi.org/10.3389/fphar.2020.01181 PMID 32848784
    14. Go↑ Nassiri-Asl M, Shariati-Rad S, Zamansoltani F. Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. BMC Complementary and Alternative Medicine, 2007 7:26 [2]
    15. Go↑ Brown E, Hurd NS, McCall S, Ceremuga TE. Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. AANA J. 2007 Oct;75(5):333-7. PMID 17966676
    16. Go↑ Paladini AC, Marder M, Viola H, Wolfman C, Wasowski C, Medina JH. Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds. J Pharm Pharmacol. 1999 May;51(5):519-26. PMID 10411210
    17. Go↑ Dhawan K, Kumar S, Sharma A. Aphrodisiac activity of methanol extract of leaves of Passiflora incarnata Linn. in mice. Phytother Res 2003;17:401–403. PMID 12722149
    18. Go↑ Dhawan K, Kumar S, Sharma A. Comparative anxiolytic activity profile of various preparations of Passiflora incarnata linneaus: a comment on medicinal plants' standardization. J Altern Complement Med. 2002 Jun;8(3):283-91. PMID 12165186
    19. Go↑ Akhondzadeh S, Naghavi HR, Vazirian M, et al. Passionflower in the treatment of generalized anxiety: A pilot double-blind randomized con- trolled trial with oxazepam. J Clin Pharm Ther 2001;26:363–367. PMID 11679026
    20. Go↑ Jean-Michel Morel. Practical treatise on phytotherapy. Ed. Grancher, 2008.
    21. Go↑ Aman U, Subhan F, Shahid M, Akbar S, Ahmad N, Ali G, Fawad K, Sewell R. Passiflora incarnata attenuation of neuropathic allodynia and vulvodynia apropos GABA-ergic and opioidergic antinociceptive and behavioural mechanisms. BMC Complementary and Alternative Medicine 2016, 16:77 (24 February 2016) Abstract texte intégral
    22. Go↑ Dhawan K. Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective. Addict Biol. 2003 Dec;8(4):379-86. PMID 14690874
    23. Go↑ Dhawan K, Dhawan S, Chhabra S. Attenuation of benzodiazepine dependence in mice by a tri-substituted benzoflavone moiety of Passiflora incarnata Linneaus: a non-habit forming anxiolytic. J Pharm Pharm Sci. 2003 May-Aug;6(2):215-22. PMID 12935433
    24. Go↑ Akhondzadeh S, Kashani L, Mobaseri M, Hosseini SH, Nikzad S, Khani M. Passionflower in the treatment of opiates withdrawal: a double-blind randomized controlled trial. J Clin Pharm Ther. 2001 Oct;26(5):369-73. PMID 11679027
    25. Go↑ Dhawan K, Kumar S, Sharma A. Reversal of cannabinoids (delta9-THC) by the benzoflavone moiety from methanol extract of Passiflora incarnata Linneaus in mice: a possible therapy for cannabinoid addiction. J Pharm Pharmacol. 2002 Jun;54(6):875-81. PMID 12079005
    26. Go↑ Rachid Soulimani, Chafique Younos, Salah Jarmouni, Dalila Bousta, René Misslin, François Mortier. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. Journal of Ethnopharmacology 57 (1997) 11–20. PMID 9234160
    27. Go↑ Fisher AA, Purcell P, The Listener DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol. 2000; 38 (1): 63-6. PMID 10696928
    28. Go↑ Maluf E, Barros HMT, Frochtengarten ML, et al. Assessment of the hypnotic/sedative effects and toxicity of Passiflora edulis aqueous extract in rodents and humans. Phytother Res 1991;5:262–266. [3]
    29. Go↑ Carrasco MC, Vallejo JR, Pardo-de-Santayana M, Peral D, Martín MA, Altimiras J. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec; 23 (12): 1795-6. doi: 10.1002 / ptr.2847. PMID 19441067
    30. Go↑ Schäfer AM, Gilgen PM, Spirgi C, Potterat O, Meyer Zu Schwabedissen HE. Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Med. 2021 Jan 28. doi: 10.1055/a-1305-3936. PMID 33511622.
    • Sharma A, Cardoso-Taketa A, García G, Villarreal ML. A systematic updated review of scientifically tested selected plants used for anxiety disorders. Botanics: Targets and Therapy, September 2012, Volume 2, Pages 21 - 39 [4]
    • Metras-de Francqueville, MJ (2003). Hawthorn, passionflower, valerian: triad of serenity. Doctoral dissertation, Jules Verne University of Picardy. abstract
    • Clavilier, B. (2009). Passiflora officinale, Passiflora incarnata L. (Passifloraceae): updating knowledge.Doctoral dissertation, University of Clermont I. abstract
    • Sarris J. Herbal medicines in the treatment of psychiatric disorders: a systematic review. Phytother Res. 2007 Aug;21(8):703-16. PMID 17562566
    • Ernst E. Herbal remedies for anxiety - a systematic review of controlled clinical trials. Phytomedicine. 2006 Feb;13(3):205-8. PMID 16428031
    • Krenn L. [Passion Flower (Passiflora incarnata L.)--a reliable herbal sedative] Wien Med Wochenschr. 2002;152(15-16):404-6. PMID 12244887
    • Zarifian E; Nordmann R, Cottet J, Queneau IP. The prescription of psychotropic drugs: use, misuse and abuse. Discussion. Bulletin of the National Academy of Medicine, 1998, vol. 182, no. 7, pp. 1365-1454 (Congress, Medical prescription - challenges and difficulties. Thematic day) [5]

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    CAUTION

    Store in a cool, dry place, away from light. Keep tightly closed, away from the reach of Children and pets.

    Do not exceed the daily dose.

     

    This product is not intended to prevent or cure any form of illness or disease.
     

    If you are pregnant or nursing ; If you have a medical condition or are in the course of medical treatment ; If you are programmed for theater/operation in the near future, please consult your healthcare practitioner before using this product.

     

    This product cannot replace a varied and balanced diet and a healthy lifestyle.

     

    This product has not been evaluated by the SAHPRA for its quality, safety or intended use.

     

    For More Information please check our General Safety Herbal products Page