May help with

• tonic
• neuroprotective
• antidepressant
• adaptogen
• hepato protective
• cardio protection
• anti inflammation
• anti hypertensive hypertension

Source : http://www.wikiphyto.org/wiki/Schisandra

Reference on http://www.wikiphyto.org

Translation in English by Google Translate  (go to the page of the source linked | on Chrome cellphones go on the 3 dots on the top right and select translate in your preferred language | on laptop right click your mouse and select option translate when hoovering on the page

plant name

Schizandra, Wu Wei Zi (Chinese), Five Flavor Seed

International Latin denomination

Schisandra chinensis (Tucz.) Baill. (Schizandra chinensis)

botanical family

Schizandraceae

Description and habitat

• Climbing plant, woody and aromatic, with pink flowers and clusters of red berries (8 m high)
• Cultivated in Northeast China
• The fruit is harvested in autumn

History and tradition

• One of the most used tonic plants in China to stimulate sexual activity
• In Chinese, it means “five fragrant plants” (recalls the flavor of the five elemental energies)
• The berries were used to retain the appearance of youth

Parts used

• Seeds, berries

Dosage forms available

Usual dosages

Composition

Main components of the plant

• Lignans , about 30 different (dibenzocyclooctadienes: schizandrin , deoxyschizandrin , gomisin )
• Triterpènes
• Essential oil
• Vitamin C and Vitamin E

Main components of buds or young shoots

Main components of essential oil

Properties

Plant properties

• Tonic, stimulates the nervous system, improves lucidity and stimulates reflexes, increases memory [1] , neuroprotective [2]
• Antidepressant, decreases irritability
• Adaptogen, facilitates resistance to stress, identical to Ginseng
• Hepatoprotective ( lignans ) especially in hepatitis (inhibits lipid peroxidation) [3] , [4] , protects against galactosamine-induced hepatotoxicity [5]
• Protects against cyclosporine-induced nephrotoxicity [6]
• Cardioprotective, inducer of HSP stress proteins (heat shock proteins) [7]
• Anti-oxidant, stimulates superoxide dismutase (SOD) and catalase activity
• Anti-hypertensive [8] , [9]
• Lung anti-inflammatory [10]
• Inducer of apoptosis in hepatocellular carcinomas (α-iso-cubebenol) [11]
• Gynecology: stimulates the uterus, increases contractions
• Sexual stimulant, male and female, increases sexual secretions

Bud properties

Properties of essential oil

Indications

Indications of the whole plant (phytotherapy)

• Toxic and viral hepatitis
• Adaptogen: asthenia, fatigue
• Male and female sexual insufficiency, anaphrodisia, impotence
• Insomnia (seemingly contradictory action)
• Neuroses, memory loss, irritability
• Alzheimer's disease (?)
• Cough, asthma
• Night sweats, quenches thirst
• Urticaria, eczema

Indications of the bud (gemmotherapy)

Specific indications of essential oil (aromatherapy)

Known or suspected mode of action

Usual formulations

Regulations

Possible side effects and precautions for use

• No side effects listed

Bibliographic references

1. Go↑ Hu D, Li C, Han N, Miao L, Wang D, Liu Z, Wang H, Yin J. Deoxyschizandrin Isolated from the Fruits of Schisandra chinensis Ameliorates Aβ1-42-induced Memory Impairment in Mice.Planta Med. 2012 Jul 6. PMID 22773410
2. Go↑ Zeng KW, Zhang T, Fu H, Liu GX, Wang XM. Schisandrin B exerts anti-neuroinflammatory activity by inhibiting the Toll-like receptor 4-dependent MyD88/IKK/NF-κB signaling pathway in lipopolysaccharide-induced microglia. Eur J Pharmacol. 2012 Jun 12. [Epub ahead of print] PMID 22698579
3. Go↑ J.L. Hancke, R.A. Burgos, F. Ahumada. Schisandra chinensis (Turcz.) Baill. Fitoterapia, Volume 70, Issue 5, 1 October 1999, Pages 451–471
4. Go↑ Chiu HF, Chen TY, Tzeng YT, Wang CK. Improvement of Liver Function in Humans Using a Mixture of Schisandra Fruit Extract and Sesamin. Phytother Res. 2012 May 21. doi: 10.1002/ptr.4702. [Epub ahead of print] PMID 22610748
5. Go↑ Kang JW, Kim SJ, Kim HY, Cho SH, Kim KN, Lee SG, Lee SM. Protective Effects of HV-P411 Complex Against D-Galactosamine-Induced Hepatotoxicity in Rats. Am J Chin Med. 2012 2012;40(3):467-480. PMID 22745064
6. Go↑ Zhu S, Wang Y, Chen M, Jin J, Qiu Y, Huang M, Huang Z. Protective Effect of Schisandrin B Against Cyclosporine A-Induced Nephrotoxicity In Vitro and In Vivo. Am J Chin Med. 2012 2012;40(3):551-566. PMID 22745070
7. Go↑ Chen N, Chiu PY, Leung HY, Ko KM. Cytochrome P-450-catalyzed reactive oxygen species production mediates the (-)schisandrin B-induced glutathione and heat shock responses in H9c2 cardiomyocytes. Indian J Pharmacol. 2012 Mar;44(2):204-9. PMID 22529476 Texte intégral
8. Alexander JS, Wang Y. Therapeutic potential of Schisandra chinensis extracts for treatment of hypertension. Introduction to: 'Antihypertensive effect of Gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability' by Park et al. Hypertens Res. 2012 Jul 5. doi: 10.1038/hr.2012.101. PMID 22763484
9. Go↑ Young Park J, Wook Yun J, Whan Choi Y, Ung Bae J, Won Seo K, Jin Lee S, Youn Park S, Whan Hong K, Kim CD. Antihypertensive effect of gomisin A from Schisandra chinensis on angiotensin II-induced hypertension via preservation of nitric oxide bioavailability. Hypertens Res. 2012 Apr 26. doi: 10.1038/hr.2012.50. PMID 22534517
10. Go↑ Bae H, Kim R, Kim Y, Lee E, Jin Kim H, Pyo Jang Y, Jung SK, Kim J. Effects of Schisandra chinensis Baillon (Schizandraceae) on lipopolysaccharide induced lung inflammation in mice. J Ethnopharmacol. 2012 Jun 26;142(1):41-7. PMID 22543173
11. Go↑ Kim JE, Kim SG, Goo JS, Park DJ, Lee YJ, Hwang IS, Lee HR, Choi SI, Lee YJ, Oh CH, Choi YW, Hwang DY. The α-iso-cubebenol compound isolated from Schisandra chinensis induces p53-independent pathway-mediated apoptosis in hepatocellular carcinoma cells. Oncol Rep. 2012 Jun 19. doi: 10.3892/or.2012.1875. PMID 22736046

Store in a cool, dry place, away from light. Keep tightly closed, away from the reach of Children and pets.

Do not exceed the daily dose.

This product is not intended to prevent or cure any form of illness or disease.
 

If you are pregnant or nursing ; If you have a medical condition or are in the course of medical treatment ; If you are programmed for theater/operation in the near future, please consult your healthcare practitioner before using this product.

This product cannot replace a varied and balanced diet and a healthy lifestyle.

This product has not been evaluated by the SAHPRA for its quality, safety or intended use.

For More Information please check our General Safety Herbal products Page