Left Continue shopping
Your Order

You have no items in your cart

Turmeric Powder Curcuma Longa - 100g - Herbal Collection

R 4950
Tax included. Shipping calculated at checkout.
4 in stock
Description

 

Turmeric Powder Curcuma Longa - 100g - Herbal Collection

 

TRADITIONALLY USED FOR

Turmeric — and especially its most active compound, curcumin — have many potential health benefits.  

 

It's a good anti-inflammatory and antioxidant.

 

INFORMATION

Source : http://www.wikiphyto.org/wiki/Turmeric

 

Reference on http://www.wikiphyto.org

 

Translation in English by Google Translate  (go to the page of the source linked | on Chrome cellphones go on the 3 dots on the top right and select translate in your preferred language | on laptop right click your mouse and select option translate when hoovering on the page

 

plant name

 

Turmeric ( Curry , Indian Saffron , Saffron Bourbon ), turmeric (English)

 

International Latin denomination

 

Curcuma longa L. = Curcuma domestica Val.

 

botanical family

 

Zingiberaceae

 

Description and habitat

 

  • Erect herbaceous species 60 to 100 cm high with creeping rhizome
  • Far East (India and Malaysia)
  • Introduced in the West Indies and Reunion
  • Aromatic rhizomatous strain of a beautiful golden yellow color in section

 

History and tradition

 

  • Turmeric is a component of curry with chilli , nutmeg , ginger , fenugreek , etc.
  • Malaysia 's Temoe-Lawaq is Curcuma xanthorriza Rosc.
  • The zedoary is another species ( Curcuma zedoaria (Christm.) Roscoe), it grows in tropical and sub-tropical rainforests, its large leaves are alternate, its aerial stems erect, its fragrant flowers are yellow, its branched tuberous rhizome is of bright orange color inside, its smell is reminiscent of mango
  • Turmeric is the subject, at the French Pharmacopoeia, of a new monograph from the Chinese Pharmacopoeia. The production of this monograph was undertaken within the framework of the cooperation agreement between the Afssaps and the Chinese State Food and Drug Administration. [1]
    • The text describes a test by thin layer chromatography which makes it possible to differentiate Curcuma longa from Curcuma xanthorrhiza . Two assay methods are included: a technique to determine the essential oil content , and a method by UV-visible spectrophotometry has been developed to assay derivatives of diccinnamoylmethane
  • In India, the prevalence of Alzheimer's disease among people aged 70 to 79 is 4.4 times lower than in the United States; the consumption of spices and in particular turmeric is thought to be the cause

 

Parts used

 

  • Rhizome (Sedge of India or Arrow root) = Turmeric fingers
  • rhizome essential oil

 

Dosage forms available

 

 

Usual dosages

 

Composition

 

Main components of the plant

 

 

Main components of buds or young shoots

 

Main components of essential oil

 

 

Properties

 

Plant properties

 

  • Anti-inflammatory, activator of the nuclear transcription factor PPAR-γ which plays a role in certain inflammatory processes [2] , [3] , the anti-inflammatory activity of curcumin has been demonstrated in models of acute and chronic inflammation, arthritis, granulomas [4] , various molecules involved in inflammation are inhibited by curcumin  : phospholipase, lipoxygenase, cyclooxygenase 2, leukotrienes, thromboxane, prostaglandins, NO, collagenase, elastase, hyaluronidase, monocyte chemoattractant protein-1 (MCP-1 ), interferon-inducible protein, tumor necrosis factor (TNF), interleukin-12 (IL-12) [5] , [6] , [7], with great job security
  • Hepatoprotective [8] , prevents hepatocyte cytotoxicity induced by carbon tetrachloride [9] and paracetamol [10] by curcumin and turmerone
    • Prevents liver damage induced by methotrexate [11] and dimethylbenzanthracene [12]
    • Preventive against cirrhosis and hepatic fibrosis [13] , [14]
  • Cholagogue effect [15]
  • Curcumin protects the kidney against oxidative stress [16]
  • Curcumin and its derivatives are antioxidants, free radical scavengers and hepatoprotectors [17]
  • Anti-ulcer, cyto-protective (but ulcerogenic at high doses), anti-Helicobacter pylori [18] , cholagogue
  • Curcumin would reduce relapses of ulcerative colitis [19]
  • Indirect action on the adrenergic cortex, inhibition of cortisone metabolism in the liver, inhibition of interleukin and TNF production
  • Immuno-modulating, immunostimulant [20] , inhibits HIV-1 integrase which catalyzes the interaction of the viral genome in the DNA of the infected cell [21]
  • Hypocholesterolemic, hypolipidemic [22] , decreases intestinal absorption of cholesterol
  • Antidiabetic [23] , improves endothelial dysfunction induced by diabetes [24] , improvement of lipid peroxidation especially with photo-irradiated curcumin [25]
  • Curcumin inhibits platelet aggregation mediated by agonists such as PAF platelet-activating factor and arachidonic acid , it inhibits the synthesis of thromboxane A2 by platelets, without the involvement of protein kinase C [26]
  • Emmenagogue, anthelmintic
  • Protects against chronic anterior uveitis
  • Anti-Alzheimer: would block the accumulation of beta-amyloid protein and destroy existing plaques [27] , improves behavior, quality of life and longevity in animal models [28]
  • Neuroprotective [29] , curcumin potentiated by piperine protects against the neurotoxic influence of 6-hydroxy dopamine (6-OHDA) [30] or quinolinic acid (inducing symptoms similar to those of Huntington's disease) [31]
  • Reduction of oxidative stress, blocking the depletion of antioxidant molecules and enzymes in erythrocytes and liver, reduction of peroxidized lipids
  • Anticancer potentials on ovarian cancer cells and lymphoma cells [32] , hepatocarcinoma cells [33] , colorectal cancer, increases body weight, decreases serum TNF-alpha, increases tumor cell apoptosis , increases the expression of the p53 molecule in tumor tissues [34]
  • Curcumin is able to inhibit carcinogenesis at three stages: angiogenesis, tumor promotion and tumor growth [35]
  • Chemoprotective against cancer chemotherapies, protective effect against cardiac, hepatic and renal toxicity of doxorubicin [36]
  • Antioxidant, promotes cancer cell apoptosis, modulates proto-oncogene expression, anti-neoangiogenic
  • In China, it would be given as a preventive measure to patients with a predisposition to cancer of the esophagus, with abnormal cells
  • Inhibits the development of skin cancers [37]
  • In contrast, even without curcumin , turmeric has anti-inflammatory, anti-cancer and anti-diabetic activities ( turmeric , turmeric , elemental , furanodene , curdione , bisacurone , cyclocurcumin , calebine A , germacrone ) and complex synergies are at work [ 38]
  • Alpha-curcumene from Curcuma xanthorriza is hypotriglyceridemic
  • The ethanolic extract of Curcuma aromatica has a repellent effect on various stinging insects, including Aedes aegypti [39] , [40]

 

Bud properties

 

Properties of essential oil

 

  • EO obtained from fresh plants has a higher antioxidant potential than that obtained from dried rhizomes [41] ( alpha-turmerone , present at 20% in EO extracted from fresh plants, is only found in state in the EO extracted from the dried rhizome) [42]
  • Antistatic [43]
  • Hepatoprotection against galactosamine by sesquiterpenes [44]
  • Ar-turmerone is neuroprotective [45]
  • Anticancer in liver cancer

 

Indications

 

Indications of the whole plant (phytotherapy)

 

  • Intermittent fevers, diarrhea
  • Liver diseases, jaundice, hepatitis
  • Urinary disorders and glomerulonephritis, renal protection
  • Osteoarthritis, arthritis [46] , 500 mg of curcumin proves to be more effective than 50 mg of diclofenac in arthritis [47] , osteoarthritis of the knee [48]
  • In knee osteoarthritis, 1500 mg/day of Curcuma domestica extract is as effective as 1200 mg/day of ibuprofen and induces fewer side effects (multicenter clinical study measuring the WOMAC Western Ontario index and McMaster Universities Osteoarthitis Index) [ 49]
  • Hypercholesterolemia, hyperlipidemia, cardiovascular prevention [50]
  • Prevention of cancers and lesions induced by cancer chemotherapy (oesophageal cancer)
  • Prevention of relapses of ulcerative colitis, Charcot-Marie disease or Déjerine disease [51]
  • Chronic anterior uveitis and AMD, curcumin protects cells of the retinal pigment epithelium against H2O2-induced oxidative damage [52] , it regulates the expression of biomarkers of cell proliferation, oxidative stress, and apoptosis retinal [53]
  • Alzheimer's disease [54] , [55]
  • Parkinson's disease ( curcumin ) [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66]
  • ALS amyotrophic lateral sclerosis (?) [67]
  • Temoe-Lawaq Curcuma xanthorriza Rosc. is active against cellulite

 

Indications of the bud (gemmotherapy)

 

Specific indications of essential oil (aromatherapy)

 

Known or suspected mode of action

 

  • Inhibition of lysosomal enzyme activity
  • Action on prostaglandin synthesis
  • Modulation of granulocyte response to inflammatory stimuli
  • Limited bioavailability due to reduced intestinal absorption and rapid elimination kinetics, dosage is very important [68]

 

Usual formulations

 

  • From 1 teaspoon to 3 tablespoons daily for an anti-inflammatory effect [6]
  • Piperine from pepper increases absorption and bioavailability of curcumin [ 69] , they are synergistic in preventing senescence [70]
  • The inclusion of piperine in formulations containing curcumin is highly recommended to inhibit curcumin glucuronidation [71].
    • Mix a full teaspoon of turmeric powder with one to two tablespoons of olive oil , grind a pinch of black pepper , to eat during the day on a food (pasta, rice, vegetables, or even in a salad)
  • The ginger-turmeric mixture also seems to be synergistic [72] , Ayurvedic medicine has used a combination of black pepper ( Piper nigrum L.), long pepper ( Piper longum L.) and ginger ( Zingiber officinale Rosc .) Since ancient times to improve the effectiveness of certain remedies [73]

 

Regulations

 

 

Possible side effects and precautions for use

 

  • Apparently no serious side effects
    • Rare digestive disorders in high doses, risk of dry mouth, flatulence, heartburn, nausea and vomiting
    • Caution in case of gastric or duodenal ulcer
    • Contraindication in case of large cholelithiasis
    • Possible contact allergies [74]
  • Pharmacokinetic interactions:
    • Few interactions with cytochromes P450 [75] , would inhibit CYP3A, CYP2C9, UGT, SULT [76] , [77]
    • Interactions with cancer drugs:
      • Combinations not recommended with certain chemotherapies (risk of partial inhibition of efficacy during treatments: Camptothecin (Campto®), doxorubicin (Adriamycine®), mechlorethamine and cyclophosphamide (Endoxan®), vincristine (Oncovin®)
      • Possible association with certain chemotherapies (experimental elements of synergy of action/potentiation of efficacy: Gemcitabine (Gemzar®), paclitaxel (Taxol®), docetaxel (Taxotère®) oxaliplatin (Eloxatine®) [78]
  • Pharmacodynamic interactions:
    • Theory with anti-inflammatory drugs
    • Avoid association with anticoagulants, inhibition of platelet aggregation [79] by modulating the biosynthesis of eicosanoids ( curcumin ) [80] , mainly products based on pure curcumin , interaction with warfarin (Coumadin)

 

Bibliographic references

 

  1. Go↑ AFSSAPS, French Pharmacopoeia. [1]
  2. Go↑ Mazidi M, Karimi E, Meydani M, Ghayour-Mobarhan M, Ferns GA. Potential effects of curcumin on peroxisome proliferator-activated receptor-γ in vitro and in vivo. World J Methodol. 2016 Mar 26;6(1):112-7. doi: 10.5662/wjm.v6.i1.112. eCollection 2016 Mar 26. PMID 27019802
  3. Go↑ Siddiqui AM, Cui X, Wu R, Dong W, Zhou M, Hu M, Simms HH, Wang P. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med. 2006 Jul;34(7):1874-82. PMID 16715036
  4. Go↑ Ammon HP, Safayhi H, Mack T, Sabieraj J. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol 1993 Mar; 38(2-3): 113-9.
  5. Go↑ Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8. PMID 12676044
  6. Go↑ Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. 2011 Mar 1;12(3):332-47. PMID 20955148
  7. Go↑ Shehzad A, Rehman G, Lee YS. Curcumin in inflammatory diseases. Biofactors. 2013 Jan-Feb;39(1):69-77. doi: 10.1002/biof.1066. PMID 23281076
  8. Go↑ Kim S, Ha K, Choi E, Jung S, Kim M, Kwon D, Yang H, Kim M, Kang H, Back H, Kim S, Park S, Baek H, Kim Y, Lee J, Chae S. The effectiveness of fermented turmeric powder in subjects with elevated alanine transaminase levels: a randomised controlled study. BMC Complementary and Alternative Medicine 2013, 13:58 (8 March 2013) Abstract Provisional PDF
  9. Go↑ Lee H, Kim S, Lee G, Choi M, Jung H, Kim Y, Kwon H, Chae H. Turmeric extract and its active compound, curcumin, protect against chronic CCl-induced liver damage by enhancing antioxidation. BMC Complementary and Alternative Medicine 2016, 16:316 (26 August 2016). Abstract texte intégral
  10. Go↑ Reyes-Gordillo K, Segovia J, Shibayama M, Vergara P, Moreno MG, Muriel P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta. 2007 Jun;1770(6):989-96.PMID 17383825
  11. Go↑ Moghadam A, Tutunchi S, Namvaran-Abbas-Abad A, Yazdi M, Bonyadi F, Mohajeri D, Mazani M, Marzban H, Los M, Ghavami S. Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress. BMC Complementary and Alternative Medicine 2015, 15:246 (22 July 2015) Abstract texte intégral
  12. Go↑ Singh Harmeet, Bedi P S, Singh B. Hepatoprotective Activity of Turmeric and Garlic against 7-12, Dimethylbenzanthracene Induced Liver Damage in Wistar Albino Rats. European Journal of Medicinal Plants. 2011 Oct-Dec; 1(4): 162-170. http://imsear.hellis.org/handle/123456789/163954
  13. Go↑ Reyes-Gordillo K, Segovia J, Shibayama M, Tsutsumi V, Vergara P, Moreno MG, Muriel P. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundamental & Clinical Pharmacology 2008 Aug;22(4):417-27. PMID 18705752
  14. Go↑ Salama SM, Abdulla MA, AlRashdi AS, Ismael S, Alkiyumi SS, Golbabapour S. Hepatoprotective effect of ethanolic extract of Curcuma longa on thioacetamide induced liver cirrhosis in rats. BMC Complementary and Alternative Medicine 2013, 13:56 (5 March 2013) Abstract Provisional PDF
  15. Go↑ Pham, T. X. (1998). Contribution to the study on cholagogue effect of curcuma, zingiberaceae in North-Vietnam. Pharmaceutical Journal, 272(12), 18-20.
  16. Go↑ Azab, A.E., Albasha, M.O., Elsayed, A.S.I. (2017) Prevention of Nephropathy by Some Natural Sources of Antioxidants. Yangtze Medicine, 1, 235-266. https://doi.org/10.4236/ym.2017.14023
  17. Go↑ Song EK, Cho H, Kim JS, Kim NY, An NH, Kim JA, Lee SH, Kim YC. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med. 2001 Dec;67(9):876-7. PMID 11745031
  18. Go↑ Mahady GB, Pendland SL, Yun G, Lu ZZ. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a Group 1 carcinogen. Anticancer research, 2002, vol. 22, no6C, pp. 4179-4181. PMID 12553052
  19. Go↑ Hanai H, Iida T, Takeuchi K, Watanabe F, Maruyama Y, Andoh A, Tsujikawa T, Fujiyama Y, Mitsuyama K, Sata M, Yamada M, Iwaoka Y, Kanke K, Hiraishi H, Hirayama K, Arai H, Yoshii S, Uchijima M, Nagata T, Koide Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol. 2006 Dec; 4 (12): 1502-6. PMID 17101300
  20. Go↑ Yue GGL, Chan BCL, Hon P-M, Fung K-P, Leung P-C, Lau CBS. Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa. International journal of biological macromolecules. 2010;47(3):342-347. doi:10.1016/j.ijbiomac.2010.05.019. texte intégral
  21. Go↑ Mesa M. Dolores, Ramirez-Tortosa M. Carmen. Nutritional and pharmacological effects of Curcuma longa L. extracts. Recent research developments in nutrition , vol. 3 (2000), pp. 157-171. [2]
  22. Go↑ Alwi I, Santoso T, Suyono S, Sutrisna B, Suyatna FD, Kresno SB, Ernie S. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med Indones. 2008 Oct;40(4):201-10. PMID 19151449
  23. Go↑ Sudha Ponnusamy, Remya Ravindran, Smita Zinjarde, Shobha Bhargava, Ameeta Ravi Kumar. Evaluation of Traditional Indian Antidiabetic Medicinal Plants for Human Pancreatic Amylase Inhibitory Effect In Vitro. Evidence-Based Complementary and Alternative Medicine Volume 2011, Article ID 515647, 10 pages doi:10.1155/2011/515647 [3]
  24. Go↑ Rungseesantivanon S, Thenchaisri N, Ruangvejvorachai P, Patumraj S. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complementary and Alternative Medicine 2010, 10:57 (14 October 2010) [4]
  25. Go↑ Thirunavukarasu Mahesh, Murali Manoharan Sri Balasubashini, Venugopal Padmanabhan Menon. Photo-Irradiated Curcumin Supplementation in Streptozotocin-Induced Diabetic Rats: Effect on Lipid Peroxidation: Photo-Irradiated Curcumin Supplementation in Streptozotocin-Induced Diabetic Rats: Effects on Lipid Peroxidation. Therapy, Volume 59, Number 6, 2004 , pp. 639-644(6)
  26. Go↑ Shah BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, Saeed SA, Gilani AH. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol. 1999 Oct 1;58(7):1167-72. PMID 10484074
  27. Go↑ Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem. 2005 Feb 18;280(7):5892-901. PMID 15590663
  28. Go↑ Wang X, Kim J, Lee S, Kim Y, Jung M, Kwon H, Ahn Y. Effects of curcuminoids identified in rhizomes of Curcuma longa on BACE-1 inhibitory and behavioral activity and lifespan of Alzheimer’s disease Drosophila models. BMC Complementary and Alternative Medicine 2014, 14:88 (5 March 2014) Abstract texte intégral
  29. Go↑ Kannappan R, Gupta SC, Kim JH, Reuter S, Aggarwal BB. Neuroprotection by spice-derived nutraceuticals: you are what you eat! Mol Neurobiol. 2011 Oct;44(2):142-59. doi: 10.1007/s12035-011-8168-2. PMID 21360003
  30. Go↑ Singh S, Kumar P. Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats. Inflammopharmacology. 2016 Nov 16. PMID 27853890
  31. Go↑ Singh S, Kumar P. Neuroprotective Activity of Curcumin in Combination with Piperine against Quinolinic Acid Induced Neurodegeneration in Rats. Pharmacology. 2016;97(3-4):151-60. doi: 10.1159/000443896. PMID 26828892
  32. Go↑ Ramadasan Kuttana, P. Bhanumathya, K. Nirmalaa, M.C. Georgea. Potential anticancer activity of turmeric (Curcuma longa). Cancer Letters, Volume 29, Issue 2, November 1985, Pages 197-202. PMID 4075289
  33. Go↑ Patial V, S M, Sharma S, Pratap K, Singh D, Padwad YS. Synergistic effect of curcumin and piperine in suppression of DENA-induced hepatocellular carcinoma in rats. Environ Toxicol Pharmacol. 2015 Sep;40(2):445-52. doi: 10.1016/j.etap.2015.07.012. PMID 26278679
  34. Go↑ He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang J. Upregulation of p53 expression in patients with colorectal cancer by administration of curcumin. Cancer Invest. 2011 Mar;29(3):208-13. doi: 10.3109/07357907.2010.550592. PMID 21314329
  35. Go↑ Amarjeet Kaur, Anita Kochhar. Role of Spices in Preventing Chronic Problems: A Review. Chem Sci Rev Lett 2017, 6(22), 1219-1226
  36. Go↑ Mohamad RH, El-Bastawesy AM, Zekry ZK, Al-Mehdar HA, Al-Said MG, Aly SS, Sharawy SM, El-Merzabani MM. The role of Curcuma longa against doxorubicin (adriamycin)-induced toxicity in rats.J Med Food. 2009 Apr;12(2):394-402. PMID 19459743
  37. Go↑ Limtrakul P, Lipigorngoson S, Namwong O, Apisariyakul A, Dunn FW. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett 1997 Jun 24; 116(2): 197-203. PMID 9215864
  38. Go↑ Aggarwal, B. B., Yuan, W., Li, S., & Gupta, S. C. (2013). Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric. Molecular nutrition & food research, 57(9), 1529–1542. https://doi.org/10.1002/mnfr.201200838. PMID 23847105
  39. Go↑ Pitasawat B, Choochote W, Tuetun B, Tippawangkosol P, Kanjanapothi D, Jitpakdi A, Riyong D. Repellency of aromatic turmeric Curcuma aromatica under laboratory and field conditions. J Vector Ecol. 2003 Dec;28(2):234-40. PMID 14714673
  40. Go↑ Choochote W, Chaiyasit D, Kanjanapothi D, Rattanachanpichai E, Jitpakdi A, Tuetun B, Pitasawat B. Chemical composition and anti-mosquito potential of rhizome extract and volatile oil derived from Curcuma aromatica against Aedes aegypti (Diptera: Culicidae). J Vector Ecol. 2005 Dec;30(2):302-9. PMID 16599168
  41. Go↑ Singh G, Kapoor IP, Singh P, de Heluani CS, de Lampasona MP, Catalan CA. Comparative study of chemical composition and antioxidant activity of fresh and dry rhizomes of turmeric (Curcuma longa Linn.). Food Chem Toxicol. 2010 Apr;48(4):1026-31. doi: 10.1016/j.fct.2010.01.015. PMID 20096323
  42. Go↑ The quality of essential oils and its influence on their effectiveness and toxicity. JOUAULT Solène, LAURAIN-MATTAR Dominique. Pharmacy thesis Academic year 2011-2012 [5]
  43. Go↑ Nwozo SO, Osunmadewa DA, Oyinloye BE. Anti-fatty liver effects of oils from Zingiber officinale and Curcuma longa on ethanol-induced fatty liver in rats. J Integr Med. 2014 Jan;12(1):59-65. doi: 10.1016/S2095-4964(14)60006-6. PMID 24461596
  44. Go↑ Miyakoshi M, Yamaguchi Y, Takagaki R, Mizutani K, Kambara T, Ikeda T, Zaman MS, Kakihara H, Takenaka A, Igarashi K. Hepatoprotective effect of sesquiterpenes in turmeric. Biofactors. 2004;21(1-4):167-70. PMID 15630192
  45. Go↑ Park SY, Jin ML, Kim YH, Kim Y, Lee SJ. Anti-inflammatory effects of aromatic-turmerone through blocking of NF-κB, JNK, and p38 MAPK signaling pathways in amyloid β-stimulated microglia. Int Immunopharmacol. 2012 Sep;14(1):13-20. doi: 10.1016/j.intimp.2012.06.003. PMID 22728094
  46. Go↑ Henrotin Y, Priem F, Mobasheri A. Curcumin: a new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. 2013 Dec;2(1):56. doi: 10.1186/2193-1801-2-56. PMID 23487030
  47. Go↑ Chandran B, Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother Res. 2012 Nov;26(11):1719-25. doi: 10.1002/ptr.4639. PMID 22407780
  48. Go↑ Madhu K, Chanda K, Saji MJ. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology. 2013 Apr;21(2):129-36. doi: 10.1007/s10787-012-0163-3. PMID 23242572
  49. Go↑ Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, Buntragulpoontawee M, Lukkanapichonchut P, Chootip C, Saengsuwan J, Tantayakom K, Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014 Mar 20;9:451-8. doi: 10.2147/CIA.S58535. eCollection 2014. PMID 24672232
  50. Go↑ Qin S1, Huang L, Gong J, Shen S, Huang J, Ren H, Hu H. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutr J. 2017 Oct 11;16(1):68. doi: 10.1186/s12937-017-0293-y. PMID 29020971
  51. Go↑ Khajavi M et coll. : "Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse : a potential therapy for inherited neuropathy." Am J Hum Genet. 2007, 81 : 438-53. PMID 17701891 texte intégral
  52. Go↑ Chang YC, Chang WC, Hung KH, Yang DM, Cheng YH, Liao YW, Woung LC, Tsai CY, Hsu CC, Lin TC, Liu JH, Chiou SH, Peng CH, Chen SJ. The generation of induced pluripotent stem cells for macular degeneration as a drug screening platform: identification of curcumin as a protective agent for retinal pigment epithelial cells against oxidative stress. Front Aging Neurosci. 2014 Aug 1;6:191. doi: 10.3389/fnagi.2014.00191. eCollection 2014. PMID 25136316
  53. Go↑ Zhu W, Wu Y, Meng YF, Wang JY, Xu M, Tao JJ, Lu J. Effect of curcumin on aging retinal pigment epithelial cells. Drug Des Devel Ther. 2015 Sep 25;9:5337-44. doi: 10.2147/DDDT.S84979. eCollection 2015. PMID 26445530
  54. Go↑ Shrikant Mishra, Kalpana Palanivelu. The effect of curcumin (turmeric) on Alzheimer's disease: An overview. Ann Indian Acad Neurol. 2008 Jan-Mar; 11(1): 13–19. texte intégral
  55. Go↑ Hishikawa N, Takahashi Y, Amakusa Y, Tanno Y, Tuji Y, Niwa H, Murakami N, Krishna UK. Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia. Ayu. 2012 Oct;33(4):499-504. doi: 10.4103/0974-8520.110524. PMID 23723666
  56. Go↑ Liu Z, Yu Y, Li X, Ross CA, Smith WW. Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism. Pharmacol Res. 2011 May;63(5):439-44. doi: 10.1016/j.phrs.2011.01.004. PMID 21237271
  57. Go↑ Harish G, Venkateshappa C, Mythri RB, Dubey SK, Mishra K, Singh N, Vali S, Bharath MM. Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease. Bioorg Med Chem. 2010 Apr 1;18(7):2631-8. doi: 10.1016/j.bmc.2010.02.029. PMID 20227282
  58. Go↑ Jagatha B, Mythri RB, Vali S, Bharath MM. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free Radic Biol Med. 2008 Mar 1;44(5):907-17. doi: 10.1016/j.freeradbiomed.2007.11.011. PMID 18166164
  59. Go↑ Ortiz-Ortiz MA, Morán JM, Ruiz-Mesa LM, Niso-Santano M, Bravo-SanPedro JM, Gómez-Sánchez R, González-Polo RA, Fuentes JM. Curcumin exposure induces expression of the Parkinson's disease-associated leucine-rich repeat kinase 2 (LRRK2) in rat mesencephalic cells. Neurosci Lett. 2010 Jan 4;468(2):120-4. doi: 10.1016/j.neulet.2009.10.081. PMID 19879924
  60. Go↑ Jiang TF, Zhang YJ, Zhou HY, Wang HM, Tian LP, Liu J, Ding JQ, Chen SD. Curcumin ameliorates the neurodegenerative pathology in A53T α-synuclein cell model of Parkinson's disease through the downregulation of mTOR/p70S6K signaling and the recovery of macroautophagy. J Neuroimmune Pharmacol. 2013 Mar;8(1):356-69. doi: 10.1007/s11481-012-9431-7. PMID 23325107
  61. Go↑ Marchiani A, Mammi S, Siligardi G, Hussain R, Tessari I, Bubacco L, Delogu G, Fabbri D, Dettori MA, Sanna D, Dedola S, Serra PA, Ruzza P. Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties. Amino Acids. 2013 Aug; 45 (2): 327-38. doi: 10.1007 / s00726-013-1503-3. PMID 23645386
  62. Go↑ Singh PK, Kotia V, Ghosh D, Mohite GM, Kumar A, Maji SK. Curcumin modulates α-synuclein aggregation and toxicity. ACS Chem Neurosci. 2013 Mar 20;4(3):393-407. doi: 10.1021/cn3001203. PMID 23509976
  63. Go↑ Mythri RB, Jagatha B, Pradhan N, Andersen J, Bharath MM. Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria? Antioxid Redox Signal. 2007 Mar;9(3):399-408. PMID 17184173
  64. Go↑ Mythri RB, Harish G, Dubey SK, Misra K, Bharath MM. Glutamoyl diester of the dietary polyphenol curcumin offers improved protection against peroxynitrite-mediated nitrosative stress and damage of brain mitochondria in vitro: implications for Parkinson's disease. Mol Cell Biochem. 2011 Jan;347(1-2):135-43. doi: 10.1007/s11010-010-0621-4. PMID 20972609
  65. Go↑ Chen J, Tang XQ, Zhi JL, Cui Y, Yu HM, Tang EH, Sun SN, Feng JQ, Chen PX. Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway. Apoptosis. 2006 Jun;11(6):943-53. PMID 16547587
  66. Go↑ Rajeswari A, Sabesan M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice. Inflammopharmacology. 2008 Apr;16(2):96-9. doi: 10.1007/s10787-007-1614-0. PMID 18408903
  67. Go↑ Cameron A, Rosenfeld J. Nutritional issues and supplements in amyotrophic lateral sclerosis and other neurodegenerative disorders. Curr Opin Clin Nutr Metab Care. 2002 Nov;5(6):631-43. PMID 12394638
  68. Go↑ Schiborr C, Kocher A, Behnam D, Jandasek J, Toelstede S, Frank J. The oral bioavailability of curcumin from micronized powder and liquid micelles is significantly increased in healthy humans and differs between sexes. Mol Nutr Food Res. 2014 Mar;58(3):516-27. doi: 10.1002/mnfr.201300724. PMID 24402825
  69. Go↑ Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May;64(4):353-6. PMID 9619120
  70. Go↑ Banji D, Banji OJ, Dasaroju S, Annamalai AR. Piperine and curcumin exhibit synergism in attenuating d-galactose induced senescence in rats. Eur J Pharmacol. 2012 Nov 29. PMID 23200897
  71. Go↑ Berginc K, Trontelj J, Basnet NS, Kristl A. Physiological barriers to the oral delivery of curcumin. Pharmazie. 2012 Jun;67(6):518-24. PMID 22822540
  72. Go↑ Bhagavathula N, Warner RL, DaSilva M, McClintock SD, Barron A, Aslam MN, Johnson KJ, Varani J. A combination of curcumin and ginger extract improves abrasion wound healing in corticosteroid-impaired hairless rat skin. Wound Repair Regen. 2009 May-Jun;17(3):360-6. doi: 10.1111/j.1524-475X.2009.00483.x. PMID 19660044
  73. Go↑ Dudhatra GB, Mody SK, Awale MM, Patel HB, Modi CM, Kumar A, Kamani DR, Chauhan BN. A comprehensive review on pharmacotherapeutics of herbal bioenhancers. ScientificWorldJournal. 2012;2012:637953. doi: 10.1100/2012/637953. PMID 23028251
  74. Go↑ Liddle M, Hull C, Liu C, Powell D. Contact urticaria from curcumin. Dermatitis. 2006 Dec;17(4):196-7. PMID 17150169
  75. Go↑ Volak LP, Hanley MJ, Masse G, Hazarika S, Harmatz JS, Badmaev V, Majeed M, Greenblatt DJ, Court MH. Effect of a herbal extract containing curcumin and piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers. Br J Clin Pharmacol. 2013 Feb;75(2):450-62. doi: 10.1111/j.1365-2125.2012.04364.x. PMID 22725836
  76. Go↑ Volak LP, Ghirmai S, Cashman JR, Court MH. Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor. Drug Metab Dispos. 2008 Aug;36(8):1594-605. doi: 10.1124/dmd.108.020552. PMID 18480186
  77. Go↑ Suresh D, Srinivasan K. Influence of curcumin, capsaicin, and piperine on the rat liver drug-metabolizing enzyme system in vivo and in vitro. Can J Physiol Pharmacol. 2006 Dec;84(12):1259-65. PMID 17487234
  78. Go↑ Dr Jean Loup Mouysset, Oncologist, Ressource association "Practical recommendations for the use of turmeric in the prevention and support of cancer treatment" www.association-ressource.org
  79. Go↑ Shah BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, Saeed SA, Gilani AH. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol. 1999 Oct 1;58(7):1167-72. PMID 10484074
  80. Go↑ Srivastava KC, Bordia A, Verma SK. Curcumin, a major component of food spice turmeric (Curcuma longa) inhibits aggregation and alters eicosanoid metabolism in human blood platelets. Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):223-7. PMID 7784468
  • Hermann P. T. Ammon, Martin A. Wahl. Pharmacology of Curcuma longa. Planta Med 1991; 57(1): 1-7
  • Sa G, Das T. Anti cancer effects of curcumin: cycle of life and death. Cell Div. 2008; 3: 14.
  • Kempaiah R.K., Srinivasan K. Influence of dietary curcumin, capsaicin and garlic on the antioxidant status of red blood cells and the liver in high-fat-fed rats. Ann. Nutr. Metab. 2004; 48(5):314-320. PMID 15467281
  • Raynaud Jean. Prescription and advice in aromatherapy. Ed. Lavoisier (Tech and Doc). 2006. p. 105
  • Cheng J, Chang G, Wu W. A controlled clinical study between hepatic arterial infusion with embolized Curcuma aromatic oil and chemical drugs in treating primary liver cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi (Chin J Integr Trad Western Med). 21: 165-167. 2001. PMID 12577327
  • Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: From ancient medicine to current clinical trials. Cell Mol Life Sci 2008; 65:1631-52. PMID 18324353
  • An Indian spice against Alzheimer's disease. Medicine and Health http://sciences.nouvelobs.com/sci_20041231.OBS5087.html

 

 

CAUTION

Store in a cool, dry place, away from light. Keep tightly closed, away from the reach of Children and pets.

Do not exceed the daily dose.

 

This product is not intended to prevent or cure any form of illness or disease.
 

If you are pregnant or nursing ; If you have a medical condition or are in the course of medical treatment ; If you are programmed for theater/operation in the near future, please consult your healthcare practitioner before using this product.

 

This product cannot replace a varied and balanced diet and a healthy lifestyle.

 

This product has not been evaluated by the SAHPRA for its quality, safety or intended use.

 

For More Information please check our General Safety Herbal products Page