May help with

• hemostatic
• anti-haemorrhagic
• antioxidant
• hepatoprotective
• antidiabetic
• anti-inflammatory
• angio protective
• PMS

Source : http://www.wikiphyto.org/wiki/Alchemille

Reference on http://www.wikiphyto.org

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plant name

Lady's Mantle , Lion's Foot , Coat of Our Lady

International Latin denomination

Alchemilla glabra Neygenf. = Alchemilla vulgaris L. = Alchemilla xanthochlora Rothm.

botanical family

Rosaceae

Description and habitat

• Perennial plant 10 to 40 cm high, woods, meadows and wet pastures throughout Europe except Mediterranean area
• Leaves with 7 - 11 shallow lobes
• Small, yellowish-green flowers arranged in corymbs
• The root stump is thick, brown, almost woody

History and tradition

• Called “plant of alchemists” because of its property of maintaining dew droplets around its leaves, which improves the harvest
• It had the reputation of curing the sterility of women and even of firming up the tissues of the genital apparatus, because of its astringent properties, for women who wanted to pass themselves off as virgins, hence its nickname "cloak of the ladies”; for this purpose, we could also use alum (aluminum and potassium sulphate, very astringent) or walnut leaves very rich in tannins like those of lady's mantle
• In the translation of Dioscorides' De Materia Medica, Andres de Laguna (1570) recommends two preparations of lady's mantle:
  • The root to treat internal and external wounds
  • The aerial parts to treat fractures in babies and young children

Parts used

• Leaves and aerial parts

Dosage forms available

• Whole plant tincture
• Fluid extract
• Dry extract
• EPS

Usual dosages

• TM  : 20 to 50 drops 3 times a day in the second part of the cycle
• EPS one teaspoon per day (idem)

Composition

Main components of the plant

• Tannins (6 - 8%) gallo-tannins and ellagitannins  : agrimoniin and laevigatine (dimers), pedunculagin (monomer), ellagic acid , sanguiine H10, castalagin , vescalagin [1]
• Proanthocyanidols , catechin , trimeric procyanidin
• Ubiquitous flavonoids (2%), glycosides and free quercetol , kaempferol , quercetin 3-O-alpha-L-arabinopyranoside [2] , luteolin-7-O-glucoside

Main components of buds or young shoots

Main components of essential oil

Properties

Plant properties

• Astringent, anti-diarrheal
• Luteinic, clinically presents progestogenic effects, without identified active principles
• Emmenagogue
• Hemostatic and anti-haemorrhagic
• Healing, vulnerary, stimulates the multiplication of epithelial cells and myofibroblasts [3]
• Tannins are antimutagenic [ 4]
• Powerful antioxidant [5] , [6] , aqueous extracts have superoxide anion scavenging properties
• Hepatoprotective, antidiabetic [7]
• Anti-inflammatory, inhibition of production of NO and pro-inflammatory cytokines ( luteolin-7-O-glucoside ), antibacterial activity ( Staphylococcus aureus , Salmonella enteritidis ) [8]
• Angio-protective [9] , [10] , elastase inhibition [11] , vasorelaxant and anti-hypertensive (methanolic extract) [12]
• Significant increase in thyroid hormone synthesis and growth of reserve follicles induced by exposure to cold [13]

Bud properties

Properties of essential oil

Directions

Indications of the whole plant (phytotherapy)

• Gynecological conditions, fibroids, endometriosis [14]
• Premenstrual syndrome
• Premenopause
• Dysmenorrhea, an Ayurvedic preparation of various herbs including lady's mantle relieves dysmenorrhea of ​​polycystic ovary syndrome [15]
• Diarrhea and gastroenteritis
• Pelvic atony (descent of organs)
• Canker sores and stomatitis [16]

Indications of the bud (gemmotherapy)

Specific indications of essential oil (aromatherapy)

Known or suspected mode of action

Usual formulations

• TM  : 20 to 50 drops two to three times a day in the second part of the cycle
• EPS one to two teaspoons per day in the second part of the cycle

Regulations

• French Pharmacopoeia list A (aerial part)

Possible side effects and precautions for use

• Not recommended in early pregnancy

Bibliographic references

1. Aller↑ Duckstein SM, Lotter EM, Meyer U, Lindequist U, Stintzing FC. Phenolic constituents from Alchemilla vulgaris L. and Alchemilla mollis (Buser) Rothm. at different dates of harvest. Z Naturforsch C. 2013 Jan-Feb;68(1-2):529-40. PMID 23687690
2. Aller↑ Fraisse D, Heitz A, Carnat A, Carnat AP, Lamaison JL. Quercetin 3-arabinopyranoside, a major flavonoid compound from Alchemilla xanthochlora. Fitoterapia. 2000 Aug;71(4):463-4. PMID 10925029
3. Aller↑ Shrivastava R, Cucuat N, John GW. Effects of Alchemilla vulgaris and glycerine on epithelial and myofibroblast cell growth and cutaneous lesion healing in rats. Phytother Res. 2007 Apr;21(4):369-73. PMID 17236169
4. Aller↑ Schimmer Oskar, Lindenbaum Monica. Tannins with Antimutagenic Properties in the Herb of Alchemilla Species and Potentilla anserina. PlantaMed 1995; 61(2): 141-145. PMID 17238069
5. Aller↑ Miroslav Ondrejovič, Zuzana Ondrigová, Janka Kubincová. Isolation of antioxidants from Alchemilla xanthochlora Nova Biotechnologica 9-3 (2009) [1]
6. Aller↑ Filipek, J. Antioxidative properties of Alchemilla xanthochlora, Salvia officinalis and Solidago virgaurea water extracts. Biology. Ser.C. (June 1994) [2]
7. Aller↑ Ozbek H, Acikara OB, Keskin I, Kirmizi NI, Ozbilgin S, Oz BE, Kurtul E, Ozrenk BC, Tekin M, Saltan G. Evaluation of hepatoprotective and antidiabetic activity of Alchemilla mollis. Biomed Pharmacother. 2017 Feb;86:172-176. doi: 10.1016/j.biopha.2016.12.005. PMID 27978496
8. Aller↑ Şeker Karatoprak G, İlgün S, Koşar M. Phenolic Composition, Anti-Inflammatory, Antioxidant, and Antimicrobial Activities of Alchemilla mollis (Buser) Rothm. Chem Biodivers. 2017 Sep;14(9). doi: 10.1002/cbdv.201700150. PMID 28502116
9. Aller↑ Jonadet M, Meunier MT, Villie F, Bastide JP, Lamaison JL. Flavonoids extracted from Ribes nigrum L. and Alchemilla vulgaris L.: 1. In vitro inhibitory activities on elastase, trypsin and chymotrypsin. 2. Angioprotective activities compared in vivo. J Pharmacol. 1986 Jan-Mar;17(1):21-7. PMID 3635653
10. Aller↑ Plotnikov MB, Aliev OI, Andreeva VY, Vasil'ev AS, Kalinkina GI. Effect of Alchemilla vulgaris extract on the structure and function of erythrocyte membranes during experimental arterial hypertension. Bull Exp Biol Med. 2006 Jun;141(6):708-11. PMID 17364056
11. Aller↑ Lamaison JL, Carnat A, Petitjean-Freytet C. Tannin content and inhibiting activity of elastase in Rosaceae. Ann Pharm Fr. 1990;48(6):335-40. PMID 2131766
12. Aller↑ Takır S, Altun IH, Sezgi B, Süzgeç-Selçuk S, Mat A, Uydeş-Doǧan BS. Vasorelaxant and blood pressure lowering effects of alchemilla vulgaris: A comparative study of methanol and aqueous extracts. Pharmacogn Mag. 2015 Jan-Mar;11(41):163-9. doi: 10.4103/0973-1296.149733. PMID 25709228
13. Aller↑ Borodin IuI, Seliatitskaia VG, Obukhova LA, Pal'chikova NA, Odintsov SV, Kukushkina TA. Effect of polyphenol fraction from Alchemilla vulgaris on the morphofunctional state of the thyroid in rats exposed to cold. Biull Eksp Biol Med. 1999 Jun;127(6):697-9. PMID 10445146 [3]
14. Aller↑ Küpeli Akkol E, Demirel MA, Bahadır Acıkara O, Süntar I, Ergene B, Ilhan M, Ozbilgin S, Saltan G, Keleş H, Tekin M. Phytochemical analyzes and effects of Alchemilla mollis (Buser) Rothm. and Alchemilla persica Rothm. in rat endometriosis model. Arch Gynecol Obstet. 2015 Feb 21. PMID 25700659
15. Aller↑ Parven, Sanjeeda. Testo induced ovulation successfully in women of polycystic ovarian syndrome. Indo American Journal of Pharmaceutical Research (2015). article available in pdf
16. Aller↑ Shrivastava R, John GW. Treatment of Aphthous Stomatitis with topical Alchemilla vulgaris in glycerine. Clin Drug Investig. 2006;26(10):567-73. PMID 17163290

• Bruneton J. Pharmacognosy, Phytochemistry, Medicinal Plants. Ed. Tec and Doc. 1997
• Wichtl Max, Anton Robert. Therapeutic plants: Tradition, officinal practice, science and therapy. Ed. Tec & Doc. Cachan. 1999.
• Fraisse D, Carnat A, Carnat AP, Lamaison JL. Standardization of the aerial parts of Alchemilla. Ann Pharm Fr. 1999 Sep;57(5):401-5. PMID 10520512
• Geiger C, Scholz E, Rimpler H. Ellagitannins from Alchemilla xanthochlora and Potentilla erecta. PlantaMed. 1994 Aug;60(4):384-5. PMID 17236062
• M. D'Agostino, I. Dini, E. Ramundo, F. Senatore. Flavonoid glycosides of Alchemilla vulgaris L. Phytotherapy Research, Volume 12, Issue S1, pages S162–S163, 1998
• Shrivastava R, Cucuat N, John GW. Effects of Alchemilla vulgaris and glycerine on epithelial and myofibroblast cell growth and cutaneous lesion healing in rats. Phytother Res. 2007 Apr;21(4):369-73. PMID 17236169

Store in a cool, dry place, away from light. Keep tightly closed, away from the reach of Children and pets.

Do not exceed the daily dose.

This product is not intended to prevent or cure any form of illness or disease.
 

If you are pregnant or nursing ; If you have a medical condition or are in the course of medical treatment ; If you are programmed for theater/operation in the near future, please consult your healthcare practitioner before using this product.

This product cannot replace a varied and balanced diet and a healthy lifestyle.

This product has not been evaluated by the SAHPRA for its quality, safety or intended use.

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