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Boldo Leaves Cut - 100 g - Herbal collection

R 12500
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Description

Boldo Leaves Cut - 100 g - Herbal collection

 Peumus boldus


    USES AND PROPERTIES

    May help with

    • Choleretic
    • Hepato protective
    • Anti atherosclerotic
    • antispasmodic
    • Neuroprotective
    • De wormer

     

     

    INDICATIONS

    Part used  Dried leaves

     

    Traditionally used for Choleretic, Mild diuretic, stomachich, mild sedative.

     

     

    DOSAGE

    Make a tisane with one to two grams of chopped leaf 

     

    Drink 2 to 3 times a day

    EFFECTS

    Bodline stimulates the production of bile and is also a mild diuretic.

    INFORMATION

    Source : http://www.wikiphyto.org/wiki/Boldo

     

    Reference on http://www.wikiphyto.org

     

    Translation in English by Google Translate  (go to the page of the source linked | on Chrome cellphones go on the 3 dots on the top right and select translate in your preferred language | on laptop right click your mouse and select option translate when hoovering on the page

     

    plant name

     

    Boldo, Boldu

     

    International Latin denomination

     

    Peumus boldus Mol. (= Peumus boldo )

     

    botanical family

     

    Monimiaceae

     

    Description and habitat

     

    • Small evergreen tree strictly localized in the part of Chile that enjoys a Mediterranean type climate
    • Dioecious species
    • Leaves with greyish-green, oval, hard and brittle blades, edges slightly rolled towards the underside
    • Grainy and rough to the touch

     

    History and tradition

     

    • The aromatic character of the crumpled leaves is reminiscent of lemon balm and mint

     

    Parts used

     

    • dried leaf

     

    Dosage forms available

     

     

    Usual dosages

     

    • Infusion 2.5 to 5 grams

     

    Composition

     

    Main components of the plant

     

     

    Main components of buds or young shoots

     

    Main components of essential oil

     

     

    Properties

     

    Plant properties

     

    • Choleretic, increases bile secretion (? Fleurentin did not find it)
    • Hepatoprotective, inhibition of lipid peroxidation [1] , protects liver against toxic effects of carbon tetrachloride [2] , protects against cisplatin toxicity [3] , liver damage produced by tert-butyl hydroperoxide [4 ] , stimulates glutathione S-transferase activity [5]
    • Anti-atherosclerotic, protects the vascular endothelium ( boldine ) [6]
    • Anti-inflammatory, boldine protects biological systems against the peroxidizing action of free radicals [7] , it is anti-inflammatory and antipyretic [8]
    • Antispasmodic [9] , relaxing effect on smooth muscle by anticholinergic mechanism
    • Antioxidant [10]
    • Hematological cytoprotection [11]
    • Neuroprotective [12]
    • Selectivity of boldine and its derivatives ( glaucine , predicentrin ) on alpha 1A adrenoceptors [13]
    • Dewormer

     

    Bud properties

     

    Properties of essential oil

     

    Directions

     

    Indications of the whole plant (phytotherapy)

     

    • Biliary insufficiency
    • Cholecystopathies
    • Spasms of smooth muscles (alpha 1A adrenoceptors)
    • Prostate problems?

     

    Indications of the bud (gemmotherapy)

     

    Specific indications of essential oil (aromatherapy)

     

    Known or suspected mode of action

     

    • Anticholinergic, parasympatholytic mechanism
    • Inhibition of lipid peroxidation
    • Selectivity of boldine and its derivatives ( glaucine , predicentrine ) on alpha 1A adrenoceptors

     

    Usual formulations

     

    Regulations

     

     

    Possible side effects and precautions for use

     

    • Contraindication in gallstones
    • Beware of long-term toxicity, the hydroalcoholic leaf extract and boldine have shown an abortive and teratogenic action as well as changes in blood biology, transaminases and urea levels in rats, without histological change however [ 14]
    • Monitor possible interactions with warfarin (one case suspected) [15]

     

    Bibliographic references

     

    1. Aller↑ Cederbaum AI, Kukiełka E, Speisky H. Inhibition of rat liver microsomal lipid peroxidation by boldine. Biochem Pharmacol. 1992 Nov 3;44(9):1765-72. PMID 1333206
    2. Aller↑ Lanhers MC, Joyeux M, Soulimani R, Fleurentin J, Sayag M, Mortier F, Younos C, Pelt JM. Hepatoprotective and anti-inflammatory effects of a traditional medicinal plant of Chile, Peumus boldus. PlantaMed. 1991 Apr;57(2):110-5. PMID 1891491
    3. Aller↑ Fernández J, Lagos P, Rivera P, Zamorano-Ponce E. Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver. Phytother Res. 2009 Jul;23(7):1024-7. PMID 19145575
    4. Aller↑ Bannach R, Valenzuela A, Cassels BK, Nunez-Vergara LJ, Speisky H. Cytoprotective and antioxidant effects of boldine on tert-butyl hydroperoxide-induced damage to isolated hepatocytes. Cell Biol Toxicol. 1996 Apr;12(2):89-100. PMID 8738478
    5. Aller↑ Kubínová R, Machala M, Minksová K, Neca J, Suchý V. Chemoprotective activity of boldine: modulation of drug-metabolizing enzymes. Pharmacy. 2001 Mar;56(3):242-3. PMID 11265593
    6. Aller↑ Lau YS, Ling WC, Murugan D, Mustafa MR. Boldine Ameliorates Vascular Oxidative Stress and Endothelial Dysfunction: Therapeutic Implication for Hypertension and Diabetes. J Cardiovasc Pharmacol. 2015 Jun;65(6):522-31. doi: 10.1097/FJC.0000000000000185. PMID 25469805
    7. Aller↑ Schmeda-Hirschmann G, Rodriguez JA, Theoduloz C, Astudillo SL, Feresin GE, Tapia A. Free-radical scavengers and antioxidants from Peumus boldus Mol. ("Boldo"). Free Radic Res. 2003 Apr;37(4):447-52. PMID 12747739
    8. Aller↑ Backhouse N, Delporte C, Givernau M, Cassels BK, Valenzuela A, Speisky H. Anti-inflammatory and antipyretic effects of boldine. Equity Agents. 1994 Oct;42(3-4):114-7. PMID 7879695
    9. Aller↑ Goetz, P. Biliary insufficiency (nonlithiasic). Continuing Education Clinical Phytotherapy. Herbal Medicine (2011) 9:172. https://doi.org/10.1007/s10298-011-0633-6
    10. Aller↑ O'Brien P, Carrasco-Pozo C, Speisky H. Boldine and its antioxidant or health-promoting properties. Chem Biol Interact. 2006 Jan 5;159(1):1-17. PMID 16221469
    11. Aller↑ Jiménez I, Garrido A, Bannach R, Gotteland M, Speisky H. Protective effects of boldine against free radical-induced erythrocyte lysis. Phytother Res. 2000 Aug;14(5):339-43. PMID 10925398
    12. Aller↑ Konrath EL, Santin K, Nassif M, Latini A, Henriques A, Salbego C. Antioxidant and pro-oxidant properties of boldine on hippocampal slices exposed to oxygen-glucose deprivation in vitro. Neurotoxicology. 2008 Nov;29(6):1136-40. PMID 18590764
    13. Aller↑ Madrero Y., Elorriaga M., Martinez S., Noguera MA, Cassels BK, D'Ocon P., and Ivorra MD A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype. Br J Pharmacol. 1996 December; 119(8): 1563–1568
    14. Aller↑ Almeida ER, Melo AM, Xavier H. Toxicological evaluation of the hydro-alcohol extract of the dry leaves of Peumus boldus and boldine in rats. Phytother Res. 2000 Mar;14(2):99-102. PMID 10685105
    15. Aller↑ Jean-Philippe Lambert, Julie Cormier. Potential Interaction between Warfarin and Boldo-Fenugreek. Pharmacotherapy, Volume21, Issue4, April 2001, Pages 509-512 https://doi.org/10.1592/phco.21.5.509.34492
    • Rakotonanahary Maldonado, Maria, 2012. Peumus boldus M.: from botany to therapy: state of knowledge in 2012. (Thesis Grenoble). 95 p. Dumas-00724069
    • Xavier Maia Mariano, Wanderson Fernando Mello de Souza, Cristiane Barbosa Rocha, Ricardo Felipe Alves Moreira. Bioactive volatile fraction of Chilean boldo (Peumus boldus Molina) – an overview. Journal of Essential Oil Research, Volume 31, 2019 - Issue 6 - Pages 474-486 https://doi.org/10.1080/10412905.2019.1617797
    • Speisky H, Cassels BK. Boldo and boldine: an emerging case of natural drug development. Pharmacol Res. 1994 Jan-Feb;29(1):1-12. PMID 8202440

    CAUTION

    Store in a cool, dry place, away from light. Keep tightly closed, away from the reach of Children and pets.

    Do not exceed the daily dose.

     

    This product is not intended to prevent or cure any form of illness or disease.
     

    If you are pregnant or nursing ; If you have a medical condition or are in the course of medical treatment ; If you are programmed for theater/operation in the near future, please consult your healthcare practitioner before using this product.

     

    This product cannot replace a varied and balanced diet and a healthy lifestyle.

     

    This product has not been evaluated by the SAHPRA for its quality, safety or intended use.

     

    For More Information please check our General Safety Herbal products Page