May help with

Adaptogen

Aids Cognition

Anti inflammatory

Tonic

Wound healer

Strengthen veins

neuroprotective

tissue healing

psoriasis

scars

memory

mental balance

leg ulcers

Source : http://www.wikiphyto.org/wiki/Hydrocotyle_asiatique

Reference on http://www.wikiphyto.org

Translation in English by Google Translate  (go to the page of the source linked | on Chrome cellphones go on the 3 dots on the top right and select translate in your preferred language | on laptop right click your mouse and select option translate when hoovering on the page

plant name

Asian pennywort, Centella , Gotu kola , Pegaga , Mandookparni

International Latin denomination

Centella asiatica (L.) Urban = Hydrocotyle asiatica L.

botanical family

Apiaceae ( Umbelliferae )

Description and habitat

• Perennial herb widely distributed in India, Indonesia, Madagascar
• Small rounded more or less heart-shaped leaves, borne on the nodes of long trailing stems, umbels of very small flowers

History and tradition

• Plant of Ayurvedic medicine and traditional Chinese medicine

Parts used

• Leaf, whole plant

Dosage forms available

• Hydrocotyle asiatica tincture whole plant
• Speciality: Madecassol®

Usual dosages

Composition

Main components of the plant

• Essential oil
• Sterols
• Flavonoids  : glycosides of flavonols
• Polyins
• Saponosides ( triterpenes , esters and acids derived from ursane ): asiatic acid , madecassic acid , madecassoside , asiaticoside ( triterpene saponoside )

Main components of buds or young shoots

Main components of essential oil

Properties

Plant properties

• Accelerates healing of superficial wounds ( asiaticoside ) [1] , and wounds in diabetics [2] , accelerates healing of burns by antioxidant effect, stimulation of collagen biosynthesis [3] , stimulation of angiogenesis [ 4]
• Antidiabetic by carbohydrase inhibition, anti-hyperglycaemic [5]
• The Pycnogenol  +  Centella asiatica combination improves the stability of atheromatous plaques [6] , [7] , especially the triterpene -rich fraction of Centella asiatica [8] , without tolerance problems or adverse effects [9]
• Stimulating effect of the reticuloendothelial system, modulation of TNF-alpha [10]
• Improves memory and learning [11] , [12] , [13] , stimulation of neuronal dendritic growth [14] , [15] , potentialities in Alzheimer's disease [16]
• Neuroprotective (brain damage) [17] against neurodegenerative diseases and especially Parkinson's disease ( asiaticoside ) [18] , [19] , [20] , [21]
• Anxiolytic [22]
• Anti-ulcer [23]
• Antitumor properties [24] , [25] , apoptosis inducer and synergy with vincristine [26]

Bud properties

Properties of essential oil

Directions

Indications of the whole plant (phytotherapy)

• Wounds and burns [27]
• Varicose ulcers in the budding stage
• Veno-lymphatic insufficiency
• Sluggish wounds, pressure sores, delayed healing of diabetic wounds, hypertrophic healing
• Diabetes (?)
• Alzheimer's (?), Parkinson's (?)

Indications of the bud (gemmotherapy)

Specific indications of essential oil (aromatherapy)

Known or suspected mode of action

• Skin indications identical to those of Calendula officinalis marigold )
• Saponosides have both a hydrophilic pole (the sugar chain(s)) and a lipophilic hydrophobic pole (the genin ), which confers surfactant properties.

Usual formulations

Regulations

• French Pharmacopoeia list A (aerial part)

Possible side effects and precautions for use

• Boone presumed harmless, no action on rat phase II enzymes [28]

Bibliographic references

1. Aller↑ Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN. In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol. 1999 Apr;65(1):1-11. PMID 10350364
2. Aller↑ Paocharoen V. The efficacy and side effects of oral Centella asiatica extract for wound healing promotion in diabetic wound patients. J Med Assoc Thai. 2010 Dec;93 Suppl 7:S166-70. PMID 21298840
3. Aller↑ Lee J, Jung E, Kim Y, Park J, Park J, Hong S, Kim J, Hyun C, Kim YS, Park D. Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling . PlantaMed. 2006 Mar;72(4):324-8. PMID 16557473
4. Aller↑ Liu M, Dai Y, Li Y, Luo Y, Huang F, Gong Z, Meng Q. Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice. PlantaMed. 2008 Jun;74(8):809-15. PMID 18484522
5. Aller↑ Kabir AU, Samad MB, D¿Costa NM, Akhter F, Ahmed A, Hannan JM. Anti-hyperglycemic activity of Centella asiatica is partly mediated by carbohydrase inhibition and glucose-fiber binding. BMC Complementary and Alternative Medicine 2014, 14:31 (18 January 2014) Abstract full text
6. Aller↑ Luzzi R, Belcaro G, Ippolito E. Carotid plaque stabilization induced by the supplement association Pycnogenol® and centella asiatica (Centellicum®). Minerva Cardioangiol. 2016 Dec;64(6):603-9. PMID 26496510
7. Aller↑ Belcaro G, Dugall M, Ippolito E, Hosoi M, Cornelli U, Ledda A, Scoccianti M, Cesarone MR, Pellegrini L, Luzzi R, Corsi M, Feragalli B. Pycnogenol® and Centella asiatica to prevent asymptomatic atherosclerosis progression in clinical events . Minerva Cardioangiol. 2017 Feb;65(1):24-31. doi: 10.23736/S0026-4725.16.04008-1. PMID 26505327
8. Aller↑ Belcaro G, Ippolito E, Dugall M, Hosoi M, Cornelli U, Ledda A, Scoccianti M, Steigerwalt RD, Cesarone MR, Pellegrini L, Luzzi R, Corsi M. Pycnogenol® and Centella asiatica in the management of asymptomatic atherosclerosis progression. Int Angiol. 2015 Apr;34(2):150-7. PMID 25519846
9. Aller↑ Belcaro G, Cornelli U. Variations in Echogenicity in Carotid and Femoral Atherosclerotic Plaques with Pycnogenol + Centella Asiatica Supplementation. Int J Angiol. 2017 Jun;26(2):95-101. doi: 10.1055/s-0036-1594292. PMID 28566935
10. Aller↑ Punturee K, Wild CP, Vinitketkumneun U. Thai medicinal plants modulate nitric oxide and tumor necrosis factor-alpha in J774.2 mouse macrophages. J Ethnopharmacol. 2004 Dec;95(2-3):183-9. PMID 15507334
11. Aller↑ Rao SB, Chetana M, Uma Devi P. Centella asiatica treatment during postnatal period enhances learning and memory in mice. Physiol Behav. 2005 Nov 15;86(4):449-57. PMID 16214185
12. Aller↑ Meena H, Pandey HK, Pandey P, Arya MC, Ahmed Z. Evaluation of antioxidant activity of two important memory enhancing medicinal plants Baccopa monnieri and Centella asiatica. Indian Journal of Pharmacology. 2012;44(1):114-117. doi:10.4103/0253-7613.91880. Full Text
13. Aller↑ Wattanathorn J, Mator L, Muchimapura S, Tongun T, Pasuriwong O, Piyawatkul N, Yimtae K, Sripanidkulchai B, Singkhoraard J. Positive modulation of cognition and mood in the healthy elderly volunteer following the administration of Centella asiatica. J Ethnopharmacol. 2008 Mar 5;116(2):325-32. doi: 10.1016/j.jep.2007.11.038. PMID 18191355
14. Aller↑ Gadahad MR, Rao M, Rao G. Enhancement of hippocampal CA3 neuronal dendritic arborization by Centella asiatica (Linn) fresh leaf extract treatment in adult rats. J Chin Med Assoc. 2008 Jan;71(1):6-13. PMID 18218554
15. Aller↑ Mohandas Rao KG, Muddanna Rao S, Gurumadhva Rao S. Centella asiatica (L.) leaf extract treatment during the growth spurt period enhances hippocampal CA3 neuronal dendritic arborization in rats. Evid Based Complement Alternate Med. 2006 Sep;3(3):349-57. PMID 16951719
16. Aller↑ Dhanasekaran M, Holcomb LA, Hitt AR, Tharakan B, Porter JW, Young KA, Manyam BV. Centella asiatica extract selectively decreases amyloid beta levels in hippocampus of Alzheimer's disease animal model. Phytother Res. 2009 Jan;23(1):14-9. doi: 10.1002/ptr.2405. PMID 19048607
17. Aller↑ Wanakhachornkrai O, Pongrakhananon V, Chunhacha P, Wanasuntronwong A, Vattanajun A, Tantisira B, Chanvorachote P, Tantisira MH. Neuritogenic effect of standardized extract of Centella asiatica ECa233 on human neuroblastoma cells. BMC Complementary and Alternative Medicine 2013, 13:204 (4 August 2013) Abstract Provisional PDF
18. Aller↑ Haleagrahara N, Ponnusamy K. Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats. J Toxicol Sci. 2010 Feb;35(1):41-7. PMID 20118623
19. Aller↑ Xu CL, Qu R, Zhang J, Li LF, Ma SP. Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats. Fitoterapia. 2013 Oct;90:112-8. doi: 10.1016/j.fitote.2013.07.009. PMID 23876367
20. Aller↑ Xu CL, Wang QZ, Sun LM, Li XM, Deng JM, Li LF, Zhang J, Xu R, Ma SP. Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax. Pharmacol Biochem Behav. 2012 Jan; 100(3):413-8. PMID 22001429
21. Aller↑ Subathra M, Shila S, Devi MA, Panneerselvam C. Emerging role of Centella asiatica in improving age-related neurological antioxidant status. Exp Gerontol. 2005 Aug-Sep;40(8-9):707-15. PMID 16026958
22. Aller↑ Jana U, Sur TK, Maity LN, Debnath PK, Bhattacharyya D. A clinical study on the management of generalized anxiety disorder with Centella asiatica. Nepal Med Coll J. 2010 Mar;12(1):8-11. PMID 20677602 Full Text
23. Aller↑ Chatterjee TK, Chakraborty A, Pathak M, Sengupta GC. Effects of plant extract Centella asiatica (Linn.) on cold restraint stress ulcer in rats. Indian J Exp Biol. 1992 Oct;30(10):889-91. PMID 1293014
24. Aller↑ Jayashree G, Kurup MG, Sudarslal VS, et al. Anti-oxidant activity of Centella asiatica on lymphoma-bearing mice[J].Fitoterapia, 2003, 74(5): 431-434
25. Aller↑ Babu TD, Kuttan G, Padikkala J. Cytotoxic and anti-tumor properties of certain texa of umbelliferae with specific reference to Centella asiatica (L.) urban[J].J Ethnopharmacol, 1995, 48(1): 53-57
26. Aller↑ Huang YH, Zhang SH, Zhen RX, et al. Asiaticoside inducing apoptosis of tumor cells and enhancing anti-tumor activity of vincristine[J].Ai Zheng, 2004, 23(12): 1599-1604
27. Aller↑ Somboonwong J, Kankaisre M, Tantisira B, Tantisira MH. Wound healing activities of different extracts of Centella asiatica in incision and burn wound models: an experimental animal study. BMC Complementary and Alternative Medicine 2012, 12:103 (20 July 2012) Abstract , Provisional PDF
28. Aller↑ Pitchayapa Seeka, Nuansri Niwattisaiwong, Mayuree H. Tantisira, Songpol Chevapat, Kridsada Anuntawuttikul, Khemchat Apipalakul, Somsong Lawanprasert. Effects of the standardized extract of Centella asiatica ECa233 on hepatic Phase II drug-metabolizing enzymes in rats. Thai Journal of Pharmaceutical Sciences, Apr 27, 2017 full text

• Zheng CJ, Qin LP. Chemical components of Centella asiatica and their bioactivities. Zhong Xi Yi Jie He Xue Bao. 2007 May;5(3):348-51. PMID 17498500 full text: [1]
• Detailed bibliography at: http://www.jcimjournal.com/en/showAbstrPage.aspx?articleid=167219772007030348

Store in a cool, dry place, away from light. Keep tightly closed, away from the reach of Children and pets.

Do not exceed the daily dose.

This product is not intended to prevent or cure any form of illness or disease.
 

If you are pregnant or nursing ; If you have a medical condition or are in the course of medical treatment ; If you are programmed for theater/operation in the near future, please consult your healthcare practitioner before using this product.

This product cannot replace a varied and balanced diet and a healthy lifestyle.

This product has not been evaluated by the SAHPRA for its quality, safety or intended use.

For More Information please check our General Safety Herbal products Page